Observational studyThe Journal of international medical research2016
Aggravation of Helicobacter pylori stomach infections in stressed military recruits.
Observational study in The Journal of international medical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Prevalence ofWorld journal of gastroenterology · 2025Article
- Impact of Relaxation and Music Intervention on Psychological and Gastrointestinal Health in Military Recruits: A Prospective Study.Therapeutics and clinical risk management · 2025Article
- Nutrition, Immune Function, and Infectious Disease in Military Personnel: A Narrative Review.Nutrients · 2023Review
- Depressive symptoms predict antibody titers after a second dose of the SARS-CoV-2 BNT162b2 vaccine among hospital workers in Japan.Brain, behavior, and immunity · 2023Observational
- Depression among people with dyspepsia and H. pylori infection: A community based cross-sectional study in Ethiopia.PloS one · 2022Article
- Prevalence ofInternational journal of general medicine · 2021Article
- The Psychotic Impact of Helicobacter pylori Gastritis and Functional Dyspepsia on Depression: A Systematic Review.Cureus · 2019Review
- Diagnosis ofPediatric gastroenterology, hepatology & nutrition · 2018Review
- Ethnic/racial differences in gastrointestinal symptoms and diagnosis associated with the risk ofClinical and experimental gastroenterology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of military stress on immune response and Helicobacter pylori stomach infections.
methodsIn this prospective, observational study, the Symptom Checklist-90 questionnaire was completed by military recruits before and following a 3-month basic training programme. H. pylori immunoglobulin (Ig)G levels, C(14)-urea breath-test values and levels of cortisol, catecholamine, and certain humoral and cellular immune responses were measured before and after the basic training.
resultsFor 60 military recruits, somatization, depression and paranoid ideation scores were significantly increased after, compared with before, basic training. Post-training H. pylori IgG detection revealed three additional cases of H. pylori infection. Post-training C(14)-urea breath-test values were significantly higher compared with before training - thus suggesting higher levels of H. pylori colonization in the stomach. Post-training cortisol and catecholamine levels were increased, while serum IgG levels were decreased; complement component (C)3 and C4 levels remained unchanged. Post-training CD4(+) and CD8(+) T-cell percentages and the CD4(+)/CD8(+) ratio were significantly reduced compared with before training. Serum interleukin (IL)-2 levels were lower and IL-10 levels were higher following training and there was a significant decrease in the IL-2/IL-10 ratio.
conclusionMilitary stress may reduce humoral and cellular immune responses and may aggravate the severity of H. pylori infection.
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