ReviewPsychopharmacology2016
Conditioned stimuli's role in relapse: preclinical research on Pavlovian-Instrumental-Transfer.
Review in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Cocaine seeking and consumption are oppositely regulated by mesolimbic dopamine in male rats.Nature communications · 2025Article
- The secondary visual cortex mediated the enhancement of associative learning on methamphetamine self-administration behaviors.Psychopharmacology · 2024Article
- Ethanol-paired conditioned stimulus effects on concurrent reinforced responding for ethanol and food.Alcohol (Fayetteville, N.Y.) · 2023Article
- The value of an action: Impact of motor behaviour on outcome processing and stimulus preference.The European journal of neuroscience · 2022Article
- Conditioned stimulus effects on paired or alternative reinforcement depend on presentation duration: Implications for conceptualizations of craving.Frontiers in behavioral neuroscience · 2022Article
- Habit, choice, and addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Review
- Ethanol-paired stimuli can increase reinforced ethanol responding.Alcohol (Fayetteville, N.Y.) · 2020Article
- Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations.Advances in pharmacology (San Diego, Calif.) · 2020Review
- Effects of rat strain and method of inducing ethanol drinking on Pavlovian-Instrumental-Transfer with ethanol-paired conditioned stimuli.Alcohol (Fayetteville, N.Y.) · 2019Article
- Cues play a critical role in estrous cycle-dependent enhancement of cocaine reinforcement.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Outcome-specific Pavlovian-to-instrumental transfer (PIT) with alcohol cues and its extinction.Alcohol (Fayetteville, N.Y.) · 2019Article
- Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats.Frontiers in behavioral neuroscience · 2019Article
- A glucocorticoid receptor antagonist reduces sign-tracking behavior in male Japanese quail.Experimental and clinical psychopharmacology · 2018Article
- Nicotine as a discriminative stimulus for ethanol use.Drug and alcohol dependence · 2018Article
- Conditioned Stimulus Form Does Not Explain Failures to See Pavlovian-Instrumental-Transfer With Ethanol-Paired Conditioned Stimuli.Alcoholism, clinical and experimental research · 2017Article
- Effects of an ethanol-paired CS on responding for ethanol and food: Comparisons with a stimulus in a Truly-Random-Control group and to a food-paired CS on responding for food.Alcohol (Fayetteville, N.Y.) · 2016Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
RATIONALE AND
objectivePavlovian learning is central to many theories of addiction. In these theories, stimuli paired with drug ingestion become conditioned stimuli (CS) and subsequently elicit drug-seeking and drug-taking. However, in most relevant studies, Pavlovian and instrumental learning are confounded. This confound may be avoided in Pavlovian-Instrumental-Transfer (PIT) procedures. In PIT, Pavlovian and instrumental learning are established separately and then combined. In order to better understand the role of CSs in addiction, we review the relevant studies using PIT.
findingsWe identified seven articles examining PIT effects of ethanol- or cocaine-paired CSs. Under at least one condition, six of these articles reported CS-elicited increases in responding previously maintained by drug. However, the only study using the optimal control condition failed to find a CS-elicited increase. Two studies examining CS specificity found the CS also increased responding maintained by a different reinforcer. Two studies examined if CSs elicit increases in actual drug-taking. Both failed to find CS-elicited increases, i.e., no study shows CS-elicited increases in actual drug-taking. Further, CS-elicited increases in extinguished responding are short-lived.
conclusionsThese findings are not entirely consistent with Pavlovian learning playing a central role in addiction. However, design issues can explain most of these inconsistencies. Studies without these design issues are needed. Additionally, existing theories hypothesize drug-paired CSs increase drug-taking by increasing motivation, by eliciting conditioned responses that make drug-seeking more probable, or by a combination of these. Work distinguishing between these mechanisms would also be useful.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.