ArticleMagnetic resonance in medicine2017
Influence of macromolecule baseline on
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Neuroimaging insights from Wistar-Kyoto rats under chronic mild stress: morphological and metabolic brain correlates of treatment-resistant depression.Scientific reports · 2026Article
- Rosette Spectroscopic Imaging for Whole-Brain Slab Metabolite Mapping at 7T: Acceleration Potential and Reproducibility.Human brain mapping · 2025Article
- Joint learning of nonlinear representation and projection for fast constrained MRSI reconstruction.Magnetic resonance in medicine · 2025Article
- GABA-edited MEGA-PRESS at 3 T: Does a measured macromolecule background improve linear combination modeling?Magnetic resonance in medicine · 2024Article
- Comparison of convolutional-neural-networks-based method and LCModel on the quantification of in vivo magnetic resonance spectroscopy.Magma (New York, N.Y.) · 2024Article
- Joint spectral quantification of MR spectroscopic imaging using linear tangent space alignment-based manifold learning.Magnetic resonance in medicine · 2023Article
- SNR Enhancement for Multi-TE MRSI Using Joint Low-Dimensional Model and Spatial Constraints.IEEE transactions on bio-medical engineering · 2022Article
- The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings.Metabolites · 2022Article
- In vivo spectral editing of phosphorylethanolamine.Magnetic resonance in medicine · 2022Article
- Contribution of macromolecules to brainNMR in biomedicine · 2021Article
- Separation of Metabolites and Macromolecules for Short-TEIEEE transactions on medical imaging · 2021Article
- Article
- Comparison of Multivendor Single-Voxel MR Spectroscopy Data Acquired in Healthy Brain at 26 Sites.Radiology · 2020Article
- UTE-SPECIAL for3D localization at an echo time of 4 ms on a clinical 3 T scanner.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Effects of different macromolecular models on reproducibility of FID-MRSI at 7T.Magnetic resonance in medicine · 2020Article
- Simultaneous mapping of metabolites and individual macromolecular components via ultra-short acquisition delayMagnetic resonance in medicine · 2018Article
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4 authors.
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Abstract
purposePoorly characterized macromolecular (MM) and baseline artefacts are known to reduce metabolite quantitation accuracy in
methodsAn experimentally acquired baseline was collected using an inversion recovery sequence (TI = 750 ms) and incorporated into the analysis method. Intrasubject reproducibility of MRSI scans, acquired at 3 Tesla, was assessed using metabolite coefficients of variance (COVs) for both experimentally acquired and simulated MM analysis schemes. In addition, the reproducibility of TE = 35 ms, 80 ms, and 144 ms was evaluated.
resultsTE = 80 ms was the most reproducible for singlet metabolites with COVs < 6% for total N-acetyl-aspartate, total creatine, and total choline; however, moderate multiplet dephasing was observed. Analysis incorporating the experimental baseline achieved higher Glu and Glx reproducibility at TE = 35 ms, and showed improvements over the simulated baseline, with higher efficacy for poorer data.
conclusionOverall, TE = 80 ms yielded the most reproducible singlet metabolite estimates. However, combined use of a short TE sequence and the experimental baseline may be preferred as a compromise between accuracy, multiplet dephasing, and T2 bias on metabolite estimates. Magn Reson Med 77:34-43, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
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