ReviewHepatology (Baltimore, Md.)2016
The plastic cellular states of liver cells: Are EpCAM and Lgr5 fit for purpose?
Review in Hepatology (Baltimore, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Identification of hepatocyte-primed cholangiocytes in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates.Cell reports · 2025Article
- Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression.Frontiers of medicine · 2024Review
- CD24Cell & bioscience · 2023Article
- Identification of a Five Immune Term Signature for Prognosis and Therapy Options (Immunotherapy versus Targeted Therapy) for Patients with Hepatocellular Carcinoma.Computational and mathematical methods in medicine · 2023Article
- The Expression of NHE8 in Liver and Its Role in Carbon Tetrachloride-Induced Liver Injury.Gastro hep advances · 2023Article
- Article
- Hepatobiliary Organoids and Their Applications for Studies of Liver Health and Disease: Are We There Yet?Hepatology (Baltimore, Md.) · 2021Review
- Characterization of CD326-positive human hepatic stem cells.Clinical and experimental hepatology · 2021Article
- Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential.British journal of cancer · 2020Review
- Increased proliferation of hepatic periportal ductal progenitor cells contributes to persistent hypermetabolism after trauma.Journal of cellular and molecular medicine · 2020Article
- Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration.Nature cell biology · 2019Article
- Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling.Stem cell reports · 2019Article
- Towards Bioengineered Liver Stem Cell Transplantation Studies in a Preclinical Dog Model for Inherited Copper Toxicosis.Bioengineering (Basel, Switzerland) · 2019Review
- Toward a Reconceptualization of Stem Cells from Cellular Plasticity.International journal of stem cells · 2019Article
- The balancing act of the liver: tissue regeneration versus fibrosis.The Journal of clinical investigation · 2018Review
- Road to stemness in hepatocellular carcinoma.World journal of gastroenterology · 2017Review
- Exosomes from mesenchymal stem cells induce the conversion of hepatocytes into progenitor oval cells.Stem cell research & therapy · 2017Article
- Regenerative Medicine and the Biliary Tree.Seminars in liver disease · 2017Review
- The evolving concept of liver cancer stem cells.Molecular cancer · 2017Review
- Stem-like plasticity and heterogeneity of circulating tumor cells: current status and prospect challenges in liver cancer.Oncotarget · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Adult liver cells have been considered restricted regarding their fate and lineage potential. That is, hepatocytes have been thought able only to generate hepatocytes and duct cells, only duct cells. While this may be the case for the majority of scenarios in a state of quiescence or homeostasis, evidence suggests that liver cells are capable of interconverting between cellular states of distinct phenotypic traits. This interconversion or plasticity had been suggested by classical studies using cellular markers, but recently lineage tracing approaches have proven that cells are highly plastic and retain an extraordinary ability to respond differently to normal tissue homeostasis, to tissue repair, or when challenged to expand ex vivo or to differentiate upon transplantation. Stemness, as "self-renewal and multipotency," seems not to be limited to a particular cell type but rather to a cellular state in which cells exhibit a high degree of plasticity and can move back and forth in different phenotypic states. For instance, upon damage cells can dedifferentiate to acquire stem cell potential that allows them to self-renew, repopulate a damaged tissue, and then undergo differentiation. In this review, we will discuss the evidence on cellular plasticity in the liver, focusing our attention on two markers, epithelial cell adhesion molecule and leucine-rich repeat-containing G protein-coupled receptor 5, which identify cells with stem cell potential. (Hepatology 2016;64:652-662).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.