ArticlePloS one2016
Progressive Induction of Type 2 Diabetes: Effects of a Reality-Like Fructose Enriched Diet in Young Wistar Rats.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Development of metabolic syndrome by increasingly fructose-enriched water in Wistar rats.Journal of molecular histology · 2026Article
- Genetics of hypertension in populations affected by the Aral Sea ecological crisis: A case-control study.PloS one · 2026Article
- The Anti-hyperglycemic and Anti-hyperlipidemic Effects of Trigonella foenum-graecum L. Seeds on Fructose-induced Diabetic Wistar Rats.Plant foods for human nutrition (Dordrecht, Netherlands) · 2024Article
- Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- Effects of Lombok Island's local moringa (Open veterinary journal · 2023Article
- An Original Asteraceae Based Infused Drink Prevents Metabolic Syndrome in Fructose-Rat Model.Antioxidants (Basel, Switzerland) · 2023Article
- The Antihyperglycemic Effect of Crude Liang (Journal of nutrition and metabolism · 2023Article
- The Marine Microalga,Nutrients · 2021Article
- Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants.Biomolecules · 2020Review
- Low utilization of glucose in the liver causes diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats.PloS one · 2020Article
- Preventive Effects of the Marine MicroalgaNutrients · 2019Article
- Triggering and resolution of inflammation in NASH.Nature reviews. Gastroenterology & hepatology · 2018Review
- Effect of personalized moderate exercise training on Wistar rats fed with a fructose enriched water.Nutrition & metabolism · 2018Article
- Metabolic Syndrome and Hypertension Resulting from Fructose Enriched Diet in Wistar Rats.BioMed research international · 2017Article
- Article
- Fructose: A Dietary Sugar in Crosstalk with Microbiota Contributing to the Development and Progression of Non-Alcoholic Liver Disease.Frontiers in immunology · 2017Review
- High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress.Molecular and cellular biochemistry · 2016Article
- Article
- Multivariate analysis and molecular interaction of curcumin with PPARγ in high fructose diet induced insulin resistance in rats.SpringerPlus · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to characterize short and medium-lasting effects of fructose supplementation on young Wistar rats. The diet was similar to actual human consumption.
methodsThree week old male rats were randomly divided into 2 groups: control (C; n = 16), fructose fed (FF; n = 16) with a fructose enriched drink for 6 or 12 weeks. Bodyweight, fasting glycemia and systolic blood pressure were monitored. Glucose tolerance was evaluated using an oral glucose tolerance test. Insulinemia was measured concomitantly and enable us to calculate insulin resistance markers (HOMA-IR, Insulin Sensitivity Index for glycemia: ISI-gly). Blood chemistry analyses were performed.
resultsAfter six weeks of fructose supplementation, rats were not overweight but presented increased fasting glycemia, reduced glucose tolerance, and lower insulin sensitivity compared to control group. Systolic blood pressure and heart weight were also increased without any change in renal function (theoretical creatinine clearance). After twelve weeks of fructose supplementation, FF rats had increased bodyweight and presented insulin resistance (higher HOMA-IR, lower ISI-gly). Rats also presented higher heart volume and lower ASAT/ALAT ratio (presumed liver lesion). Surprisingly, the Total Cholesterol/Triglycerides ratio was increased only after six weeks of fructose supplementation, predicting a higher LDL presence and thus a higher risk of developing cardiovascular disease. This risk was no longer present after twelve weeks of a fructose enriched diet.
conclusionOn young Wistar rats, six weeks of fructose supplementation is sufficient to induce signs of metabolic syndrome. After twelve weeks of fructose enriched diet, rats are insulin resistant. This model enabled us to study longitudinally the early development of type 2 diabetes.
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