Evidence map›Paper›PMID 26799589›Full record

ArticleOncotarget2016

Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients.

Tianzhao Xu, Qiulian Zhou, Lin Che, Saumya Das, Lemin Wang, Jinfa Jiang, Guanghe Li, Jiahong Xu, Jianhua Yao, Hongbao Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  14. Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tianzhao XuRegeneration and Ageing Lab, Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai 200444, China.
Qiulian ZhouRegeneration and Ageing Lab, Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai 200444, China.
Lin CheDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Saumya DasCardiovascular Division of the Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Lemin WangDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Jinfa JiangDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Guanghe LiDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Jiahong XuDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Jianhua YaoDepartment of Cardiology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.
Hongbao WangDepartment of Cardiology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.
Yue DaiDepartment of Cardiology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.
Junjie XiaoRegeneration and Ageing Lab, Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai 200444, China.

Funding

Impact of circadian rhythm in obtaining reference profiles of exRNAs in healthy iU01HL126497 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GHIRAN, IONITA CALIN · 2014 to 2018
$3.3M
Plasma miRNA predictors of adverse mechanical and electrical remodeling after MIUH3TR000901 · NCATS · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA, KWONG, RAYMOND Y · 2015 to 2017
$3.2M
Novel Role for Circulating extracellular RNAs in Human Heart FailureR01HL122547 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA · 2015 to 2019
$2.1M
NCATS NIH HHS UH3 TR000901NHLBI NIH HHS R01 HL122547NHLBI NIH HHS U01 HL126497
6 · The paper itself

Abstract

Congestive heart failure (CHF) is a major cause of hospitalizations, morbidity, and mortality in Western societies. In addition to optimal medical and device therapy, exercise training is an important adjunct treatment option for CHF patients. MicroRNAs (miRNAs, miRs) participate in a variety of physiological and pathological processes. Dynamic regulation of circulating miRNAs during exercise in healthy persons and athletes has recently been documented, however, the response of circulating miRNAs to exercise in CHF patients is undetermined. Twenty-eight CHF patients underwent a symptom-limited incremental cardiopulmonary exercise test on a bicycle ergometer using a standardized exercise protocol of revised Ramp10 programs at Shanghai Tongji Hospital. Blood samples were collected before and immediately after an acute exercise session. RNA was extracted from the serum and selected miRNAs were determined using quantitative polymerase chain reactions. Moreover, inflammatory and muscle damage markers were determined by enzyme linked immunosorbent assays. We found that serum miR-21, miR-378 and miR-940 levels were significantly up-regulated immediately following an acute exercise while the rest were not changed. In addition, no robust correlation was identified between changes of these miRNAs and exercise capacity, muscle damage or inflammation. In conclusion, serum miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in CHF patients. Further studies are needed to clarify the potential use of circulating miRNAs as biomarkers of exercise adaptation in CHF patients, and if they have any use as prognostic markers of cardiovascular outcomes.

Indexed as

Adaptation, PhysiologicalBiomarkersCohort StudiesExerciseFemaleHeart FailureHumansMaleMicroRNAsMiddle AgedBiomarkersMicroRNAsexerciseheart failuremicroRNA

Identifiers

PMID26799589
PMCPMC4914295

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.