ArticlePharmaceutical biology2016
In vitro antimicrobial and anti-proliferative activities of plant extracts from Spathodea campanulata, Ficus bubu, and Carica papaya.
Article in Pharmaceutical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Spathodea campanulata extract as an endodontic irrigant against Enterococcus faecalis: an in vitro and ex vivo study.Head & face medicine · 2026Article
- Evaluation of Anti-Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Bridging the Chemical Profiles and Biological Effects ofMolecules (Basel, Switzerland) · 2022Article
- Review
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- New Insights into Bioactive Compounds from the Medicinal PlantAntibiotics (Basel, Switzerland) · 2020Article
- The complete chloroplast genome sequence ofMitochondrial DNA. Part B, Resources · 2019Article
- Anticandidal Potential of Stem Bark Extract fromMolecules (Basel, Switzerland) · 2019Article
- Natural products: a hope for glioblastoma patients.Oncotarget · 2018Review
- Biological activities of plant extracts fromSaudi journal of biological sciences · 2018Article
- Plants' Natural Products as Alternative Promising Anti-Pharmacognosy reviewsReview
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAfrican medicinal plants represent a prominent source of new active substances. In this context, three plants were selected for biological investigations based on their traditional uses.
objectiveThe antimicrobial and anti-proliferative features of three plants used for medicinal purpose were evaluated. MATERIALS AND
methodsThe antimicrobial activities of methanol extracts of Ficus bubu Warb. (Moraceae) stem bark and leaves, of Spathodea campanulata P. Beauv. (Bignoniaceae) flowers, as well as those of Carica papaya Linn. (Caricaceae) latex, were determined using the microbroth dilution method against a set of bacteria and fungi pathogens including: Enterococcus faecalis, Staphylococcus aureus, S. saprophyticus, S. epidermididis, Escherichia coli, Klebsiella pneumonia, Salmonella typhimurium, Candida albicans, and Trichophyton rubrum. The tested concentrations of extracts ranged from 2500.0 to 2.4 μg/mL and MIC values were evaluated after 24 h incubation at 37 °C. Subsequently, MTT assay was used to estimate anti-proliferative activity of these methanol extracts and of F. bubu latex on three human cancer cell lines (U373 glioblastoma, A549 NSCLC, and SKMEL-28 melanoma).
resultsThe methanol extract of F. bubu stem bark exhibited the highest antimicrobial activity against C. albicans with a MIC value of 9.8 μg/mL, while the F. bubu latex and the methanol extract of F. bubu leaves induced significant anti-proliferative activity against lung (IC50 values of 10 and 14 μg/mL, respectively) and glioma (IC50 values of 13 and 16 μg/mL, respectively) cancer cells.
conclusionThese results indicate that effective drugs could be derived from the three studied plants.
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