Evidence map›Paper›PMID 26798846›Full record

ArticleJournal of bone marrow research2015

Bone Marrow Stem Cell Contribution to Pulmonary Homeostasis and Disease.

Lindsay T McDonald, Amanda C LaRue

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone marrow research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lindsay T McDonaldResearch Services, Ralph H Johnson VAMC, Charleston, SC, USA; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA.
Amanda C LaRueResearch Services, Ralph H Johnson VAMC, Charleston, SC, USA; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.
Medical University of South Carolina · US

Funding

Hematopoietic Stem Cell-Derived Carcinoma Associated Fibroblasts in TumorR01CA148772 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LARUE, AMANDA C. · 2011 to 2015
$1.3M
Targeting HSC-derived Circulating Fibroblast Precursors in Pulmonary FibrosisI01BX002277 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI LARUE, AMANDA C. · 2014 to 2017
–
BLRD VA I01 BX002277NCI NIH HHS R01 CA148772
6 · The paper itself

Abstract

The understanding of bone marrow stem cell plasticity and contribution of bone marrow stem cells to pathophysiology is evolving with the advent of innovative technologies. Recent data has led to new mechanistic insights in the field of mesenchymal stem cell (MSC) research, and an increased appreciation for the plasticity of the hematopoietic stem cell (HSC). In this review, we discuss current research examining the origin of pulmonary cell types from endogenous lung stem and progenitor cells as well as bone marrow-derived stem cells (MSCs and HSCs) and their contributions to lung homeostasis and pathology. We specifically highlight recent findings from our laboratory that demonstrate an HSC origin for pulmonary fibroblasts based on transplantation of a clonal population of cells derived from a single HSC. These findings demonstrate the importance of developing an understanding of the sources of effector cells in disease state. Finally, a perspective is given on the potential clinical implications of these studies and others addressing stem cell contributions to lung tissue homeostasis and pathology.

Indexed as

Bone marrow stem cellsHematopoietic stem cellsMesenchymal stem cellsPulmonary homeostasisTissue regeneration

Identifiers

PMID26798846
PMCPMC4718580
OpenAlexW1758025850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.