ArticleOpen forum infectious diseases2016
Burden of Nursing Home-Onset Clostridium difficile Infection in the United States: Estimates of Incidence and Patient Outcomes.
Article in Open forum infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Global burden ofJournal of global health · 2019Pooled it
- Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Guideline
- Trends and Disparities inGastroenterology research and practice · 2026Article
- The Global Burden ofInfectious disease reports · 2025Review
- Article
- The burden of CDI in the United States: a multifactorial challenge.BMC infectious diseases · 2023Review
- Reimagining Infection Control in U.S. Nursing Homes in the Era of COVID-19.Journal of the American Medical Directors Association · 2022Article
- An emergent infectious disease: Clostridioides difficile infection hospitalizations, 10-year trend in Sicily.Infection · 2021Article
- Pragmatic Strategy for Fecal Specimen Storage and the Corresponding Test Methods forPathogens (Basel, Switzerland) · 2021Article
- Facilitators and challenges experienced by nursing homes enrolling in the CDC national health care safety network.American journal of infection control · 2021Article
- Article
- Palliative care and infection management at end of life in nursing homes: A descriptive survey.Palliative medicine · 2020Article
- Changes in US Nursing Home Infection Prevention and Control Programs From 2014 to 2018.Journal of the American Medical Directors Association · 2020Article
- U.S.-Based National Surveillance for Fidaxomicin Susceptibility of Clostridioides difficile-Associated Diarrheal Isolates from 2013 to 2016.Antimicrobial agents and chemotherapy · 2019Article
- The IOU Consensus Recommendations for Empirical Therapy of Cystitis in Nursing Home Residents.Journal of the American Geriatrics Society · 2019Article
- Vaccines for enteric diseases.Human vaccines & immunotherapeutics · 2019Article
- Increasing Age Has Limited Impact on Risk ofOpen forum infectious diseases · 2018Article
- Bioprospecting saline gradient of a Wildlife Sanctuary for bacterial diversity and antimicrobial activities.BMC research notes · 2017Article
- Acid-Suppressive Therapy and Risk of Infections: Pros and Cons.Clinical drug investigation · 2017Review
- Challenges and Strategies for Prevention of Multidrug-Resistant Organism Transmission in Nursing Homes.Current infectious disease reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Approximately 4 million Americans receive nursing home (NH) care annually. Nursing home residents commonly have risk factors for Clostridium difficile infection (CDI), including advanced age and antibiotic exposures. We estimated national incidence of NH-onset (NHO) CDI and patient outcomes. Methods. We identified NHO-CDI cases from population-based surveillance of 10 geographic areas in the United States. Cases were defined by C difficile-positive stool collected in an NH (or from NH residents in outpatient settings or ≤3 days after hospital admission) without a positive stool in the prior 8 weeks. Medical records were reviewed on a sample of cases. Incidence was estimated using regression models accounting for age and laboratory testing method; sampling weights were applied to estimate hospitalizations, recurrences, and deaths. Results. A total of 3503 NHO-CDI cases were identified. Among 262 sampled cases, median age was 82 years, 76% received antibiotics in the 12 weeks prior to the C difficile-positive specimen, and 57% were discharged from a hospital in the month before specimen collection. After adjusting for age and testing method, the 2012 national estimate for NHO-CDI incidence was 112 800 cases (95% confidence interval [CI], 93 400-131 800); 31 400 (28%) were hospitalized within 7 days after a positive specimen (95% CI, 25 500-37 300), 20 900 (19%) recurred within 14-60 days (95% CI, 14 600-27 100), and 8700 (8%) died within 30 days (95% CI, 6600-10 700). Conclusions. Nursing home onset CDI is associated with substantial morbidity and mortality. Strategies focused on infection prevention in NHs and appropriate antibiotic use in both NHs and acute care settings may decrease the burden of NHO CDI.
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