ArticleJournal of diabetes research2016
Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity.
Article in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Exercise training alters the genomic response to acute exercise in human adipose tissue.Epigenomics · 2018Trial
- Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs.Epigenetics · 2023Article
- Immune response to arbovirus infection in obesity.Frontiers in immunology · 2022Review
- A simple flow cytometry-based assay to study global methylation levels in onion, a non-model species.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Obesity and severe coronavirus disease 2019: molecular mechanisms, paths forward, and therapeutic opportunities.Theranostics · 2021Review
- Diet-Dependent Changes of the DNA Methylome Using a Göttingen Minipig Model for Obesity.Frontiers in genetics · 2021Article
- Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Review
- Chronic stress, epigenetics, and adipose tissue metabolism in the obese state.Nutrition & metabolism · 2020Review
- The mediating effect of immune markers on the association between ambient air pollution and adult-onset asthma.Scientific reports · 2019Article
- Genes controlling the activation of natural killer lymphocytes are epigenetically remodeled in intestinal cells from germ-free mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Fra-2 Expression in Osteoblasts Regulates Systemic Inflammation and Lung Injury through Osteopontin.Molecular and cellular biology · 2018Article
- T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors.Clinical epigenetics · 2018Article
- Deregulation of obesity-relevant genes is associated with progression in BMI and the amount of adipose tissue in pigs.Molecular genetics and genomics : MGG · 2018Article
- Cardiac Hypertrophy and Brain Natriuretic Peptide Levels in an Ovariectomized Rat Model Fed a High-Fat Diet.Medical science monitor basic research · 2017Article
- Obesity altered T cell metabolism and the response to infection.Current opinion in immunology · 2017Review
- Fat and carbohydrate content in the diet induces drastic changes in gene expression in young Göttingen minipigs.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- The most important questions in cancer research and clinical oncology-Question 2-5. Obesity-related cancers: more questions than answers.Chinese journal of cancer · 2017Article
- The initiation of metabolic inflammation in childhood obesity.The Journal of clinical investigation · 2017Review
- Particulate matter exposure is associated with inflammatory gene methylation in obese subjects.Environmental research · 2017Article
- Joint Profiling of miRNAs and mRNAs Reveals miRNA Mediated Gene Regulation in the Göttingen Minipig Obesity Model.PloS one · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is associated with immunological perturbations that contribute to insulin resistance. Epigenetic mechanisms can control immune functions and have been linked to metabolic complications, although their contribution to insulin resistance still remains unclear. In this study, we investigated the link between metabolic dysfunction and immune alterations with the epigenetic signature in leukocytes in a porcine model of obesity. Global DNA methylation of circulating leukocytes, adipose tissue leukocyte trafficking, and macrophage polarisation were established by flow cytometry. Adipose tissue inflammation and metabolic function were further characterised by quantification of metabolites and expression levels of genes associated with obesity and inflammation. Here we show that obese pigs showed bigger visceral fat pads, higher levels of circulating LDL cholesterol, and impaired glucose tolerance. These changes coincided with impaired metabolism, sustained macrophages infiltration, and increased inflammation in the adipose tissue. Those immune alterations were linked to global DNA hypermethylation in both B-cells and T-cells. Our results provide novel insight into the possible contribution of immune cell epigenetics into the immunological disturbances observed in obesity. The dramatic changes in the transcriptomic and epigenetic signature of circulating lymphocytes reinforce the concept that epigenetic processes participate in the increased immune cell activation and impaired metabolic functions in obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.