ReviewBioMed research international2015
Fluid Therapy: Double-Edged Sword during Critical Care?
Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05046340 (Applicability of Fluid Responsiveness Indices in Patients With Acute Circulatory Failure), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Applicability of Fluid Responsiveness Indices in Patients With Acute Circulatory Failure (AFRIC Study)
Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Effect of focused cardiopulmonary ultrasonography on clinical outcome of septic shock: a randomized study.The Journal of international medical research · 2021Trial
- Personalized fluid resuscitation may reduce mortality in septic shock as compared with fixed-volume approach - a systematic review and meta-analysis of randomized controlled trials.Intensive care medicine experimental · 2026Article
- Perioperative Predictors of Complications and Flap Loss in Microvascular Reconstructive Surgery: The Role of Fluid Balance, Crystalloid Administration and Operative Time.Journal of clinical medicine · 2026Article
- Usability Validation of an Integrated Hemodynamic and Pulmonary Monitoring System Using Eye-Tracking Analysis.Journal of clinical medicine · 2026Article
- Wearable and noninvasive monitoring of fluid shifts: A pilot study assessing a novel bioimpedance sensor during lower body negative pressure.Physiological reports · 2025Article
- Article
- Diagnostic accuracy of left ventricular outflow tract velocity time integral versus inferior vena cava collapsibility index in predicting post-induction hypotension during general anesthesia: an observational study.Acute and critical care · 2024Article
- Associations between fluid overload and outcomes in critically ill patients with acute kidney injury: a retrospective observational study.Scientific reports · 2023Observational
- Usefulness of the velocity-time integral of the left ventricular outflow tract variability index to predict fluid responsiveness in patients undergoing cardiac surgery.Echo research and practice · 2023Article
- Invasive and Non-invasive Dynamic Parameters to Predict Fluid Responsiveness After Off-pump Coronary Surgery.Turkish journal of anaesthesiology and reanimation · 2022Article
- Incoherence between Systemic Hemodynamic and Microcirculatory Response to Fluid Challenge in Critically Ill Patients.Journal of clinical medicine · 2021Article
- Change in Carotid Blood Flow and Carotid Corrected Flow Time Assessed by Novice Sonologists Fails to Determine Fluid Responsiveness in Spontaneously Breathing Intensive Care Unit Patients.Ultrasound in medicine & biology · 2020Observational
- The Effect of Fluid Overload on Attributable Morbidity after Cardiac Surgery: A Retrospective Study.Critical care research and practice · 2020Article
- Endothelial glycocalyx in acute care surgery - what anaesthesiologists need to know for clinical practice.BMC anesthesiology · 2019Review
- How to detect a positive response to a fluid bolus when cardiac output is not measured?Annals of intensive care · 2019Article
- Heart-lung interactions, a long story with many pioneers.Annals of translational medicine · 2018Article
- Principles of fluid management and stewardship in septic shock: it is time to consider the four D's and the four phases of fluid therapy.Annals of intensive care · 2018Review
- Anesthesia-Associated Relative Hypovolemia: Mechanisms, Monitoring, and Treatment Considerations.Frontiers in veterinary science · 2018Article
- A Different Approach to the Nutritional Therapy in Intensive Care Units: Nutrition Software (ICNUS).Turkish journal of anaesthesiology and reanimation · 2017Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluid therapy is still the mainstay of acute care in patients with shock or cardiovascular compromise. However, our understanding of the critically ill pathophysiology has evolved significantly in recent years. The revelation of the glycocalyx layer and subsequent research has redefined the basics of fluids behavior in the circulation. Using less invasive hemodynamic monitoring tools enables us to assess the cardiovascular function in a dynamic perspective. This allows pinpointing even distinct changes induced by treatment, by postural changes, or by interorgan interactions in real time and enables individualized patient management. Regarding fluids as drugs of any other kind led to the need for precise indication, way of administration, and also assessment of side effects. We possess now the evidence that patient centered outcomes may be altered when incorrect time, dose, or type of fluids are administered. In this review, three major features of fluid therapy are discussed: the prediction of fluid responsiveness, potential harms induced by overzealous fluid administration, and finally the problem of protocol-led treatments and their timing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.