ArticleBioMed research international2015
Iron Deposition Is Positively Related to Cognitive Impairment in Patients with Chronic Mild Traumatic Brain Injury: Assessment with Susceptibility Weighted Imaging.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Pooled it
- Ultrashort Echo Time Quantitative Susceptibility Source Separation in Musculoskeletal System: A Feasibility Study.Journal of imaging · 2026Article
- Traumatic brain injury-related ferroptosis: current perspectives.Journal of molecular medicine (Berlin, Germany) · 2025Review
- Fer-1 alleviates traumatic brain injury-induced cognitive impairment by inhibiting hippocampal ferroptosis.IBRO neuroscience reports · 2025Article
- Effects of Motion in Ultrashort Echo Time Quantitative Susceptibility Mapping for Musculoskeletal Imaging.Journal of imaging · 2025Article
- Characterizing positive and negative quantitative susceptibility values in the cortex following mild traumatic brain injury: a depth- and curvature-based study.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Mild traumatic brain injury increases cortical iron: evidence from individual susceptibility mapping.Brain communications · 2025Article
- Brain structural and functional abnormalities associated with acute post-traumatic headache: iron deposition and functional connectivity.The journal of headache and pain · 2024Article
- Implications of Iron in Ferroptosis, Necroptosis, and Pyroptosis as Potential Players in TBI Morbidity and Mortality.ASN neuro · 2024Review
- Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury.Neural regeneration research · 2023Review
- Genomic evaluation of novel Kenyan virulent phage isolates infecting carbapenemase-producing Klebsiella pneumoniae and safety determination of their lysates in Balb/c mice.Archives of microbiology · 2022Article
- Susceptibility-weighted Imaging for Renal Iron Overload Assessment: A Pilot Study.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Neuropathological Mechanisms of Mild Traumatic Brain Injury: A Perspective From Multimodal Magnetic Resonance Imaging.Frontiers in neuroscience · 2022Review
- Multimodal magnetic resonance imaging of youth sport-related concussion reveals acute changes in the cerebellum, basal ganglia, and corpus callosum that resolve with recovery.Frontiers in human neuroscience · 2022Article
- Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury.Brain and behavior · 2021Article
- Noninvasive magnetic resonance imaging techniques in mild traumatic brain injury research and diagnosis.Human brain mapping · 2021Review
- Iron Metabolism Disorders for Cognitive Dysfunction After Mild Traumatic Brain Injury.Frontiers in neuroscience · 2021Review
- The Role of Iron, Its Metabolism and Ferroptosis in Traumatic Brain Injury.Frontiers in cellular neuroscience · 2020Review
- Ferroptosis in Acute Central Nervous System Injuries: The Future Direction?Frontiers in cell and developmental biology · 2020Article
- Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice.CNS neuroscience & therapeutics · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate the usability of SWI in assessment of brain iron to detect cognitive dysfunction in patients with chronic mild traumatic brain injury (mTBI).
methods39 patients with mTBI and 37 normal controls were given the Mini-Mental State Examination (MMSE) and underwent SWI scanning at least 6 months after injury. Angle radian values were calculated with phase images. The angle radian values were compared between groups using analysis of covariance, and their association with MMSE scores was analyzed using Spearman correlations.
resultsSignificantly higher angle radian values (p < 0.05) were found in the head of the caudate nucleus, the lenticular nucleus, the hippocampus, the thalamus, the right substantia nigra, the red nucleus, and the splenium of the corpus callosum (SCC) in the mTBI group, compared to the control group. MMSE scores were negatively correlated with angle radian values in the right substantia nigra (r = -0.685, p < 0.001).
conclusionsPatients with chronic mTBI might have abnormally high accumulations of iron, and their MMSE scores are negatively associated with angle radian values in the right substantia nigra, suggesting a role of SWI in the assessment of cognitive impairments of these patients.
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