2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors.

D A Babkov, M P Paramonova, A A Ozerov, A L Khandazhinskaya, R Snoeck, G Andrei, M S Novikov

Abstract read

In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

D A BabkovVolgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.

M P ParamonovaVolgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.

A A OzerovVolgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.

A L KhandazhinskayaEngelhardt Institute of Molecular Biology, Russian Academy of Science, Vavilov Str., 32, Moscow, 119991 , Russia.

R SnoeckRega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium.

G AndreiRega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium.

M S NovikovVolgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of novel uracil derivatives, bearing N-(4-phenoxyphenyl)acetamide moiety at N3 of a pyrimidine ring, has been synthesized. Their antiviral activity has been evaluated. It has been found that the novel compounds possess high inhibitory activity against replication of human cytomegalovirus (AD-169 and Davis strains) in HEL cell cultures. In addition, some of the derivatives proved to be inhibitory against varicella zoster virus.

Indexed as

antiviral activityhuman cytomegalovirussynthesisuracil derivatives

Identifiers

PMID26798502

PMCPMC4717260

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.