Evidence map›Paper›PMID 26798455›Full record

ArticleClinical kidney journal2016

Redox homeostasis, T cells and kidney diseases: three faces in the dark.

Luca Simeoni, Christoph Thurm, Andreas Kritikos, Andreas Linkermann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical kidney journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Genetic disruption ofAmerican journal of physiology. Renal physiology · 2019
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Luca SimeoniOtto-von-Guericke University, Institute of Molecular and Clinical Immunology , Magdeburg , Germany.
Christoph ThurmOtto-von-Guericke University, Institute of Molecular and Clinical Immunology , Magdeburg , Germany.
Andreas KritikosOtto-von-Guericke University, Institute of Molecular and Clinical Immunology , Magdeburg , Germany.
Andreas LinkermannClinic for Nephrology and Hypertension , Christian-Albrechts-University Kiel , Germany.
Otto-von-Guericke University Magdeburg · DEKiel University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The redox equilibrium is crucial for the maintenance of immune homeostasis. Here, we summarize recent data showing that oxidation regulates T-cell functions and that alterations of the redox equilibrium may play an important role in the pathogenesis of inflammatory conditions affecting the kidneys. We further discuss potential links between oxidation, T cells and renal diseases such as systemic lupus erythematosus, renal ischaemia/reperfusion injury, end-stage renal disease and hypertension. The basic understanding of oxidation as a means by which diseases are directly affected results in unexpected pathophysiological similarities. Finally, we describe potential therapeutic options targeting redox systems for the treatment of nephropathies affecting humans.

Indexed as

acute kidney injuryautoimmunityend-stage kidney diseasesystemic lupus erythematosus (SLE)T-cell activation

Identifiers

PMID26798455
PMCPMC4720211
OpenAlexW2202660988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.