Evidence map›Paper›PMID 26798451›Full record

ArticleHepatic oncology

The role of AEG-1 in the development of liver cancer.

Chadia L Robertson, Jyoti Srivastava, Devaraja Rajasekaran, Rachel Gredler, Maaged A Akiel, Nidhi Jariwala, Ayesha Siddiq, Luni Emdad, Paul B Fisher, Devanand Sarkar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hepatic oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. MicroRNA-96: A therapeutic and diagnostic tumor marker.Iranian journal of basic medical sciences · 2022
    Review
  3. Article
  4. Review
  5. Assessment of Current Gene Therapy Practices in Hepatocellular Carcinoma.Gastrointestinal disorders (Basel, Switzerland) · 2020
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chadia L RobertsonDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
Jyoti SrivastavaDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
Devaraja RajasekaranDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
Rachel GredlerDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
Maaged A AkielDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
Nidhi JariwalaDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
Ayesha SiddiqDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA.
Luni EmdadDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA; VCU Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA.
Paul B FisherDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA; VCU Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Molecular Medicine Research Building 1220 East Broad Street, 7th Floor PO Box 980033, Richmond, VA 23298-0033, USA.
Devanand SarkarDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Sanger Hall, Room 11-0051101 East Marshall Street, PO Box 980033, Richmond, VA 23298-0033, USA; VCU Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Molecular Medicine Research Building 1220 East Broad Street, 7th Floor PO Box 980033, Richmond, VA 23298-0033, USA.
Virginia Commonwealth University · US

Funding

Training Grant in Digestive Diseases and Liver DiseasesT32DK007150 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SANYAL, ARUN J · 1986 to 2017
$4.2M
Analysis of a novel regulator of hepatocellular carcinomaR01CA138540 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SARKAR, DEVANAND · 2010 to 2014
$1.6M
NCI NIH HHS R01 CA138540NIDDK NIH HHS T32 DK007150
6 · The paper itself

Abstract

AEG-1 is an oncogene that is overexpressed in all cancers, including hepatocellular carcinoma. AEG-1 plays a seminal role in promoting cancer development and progression by augmenting proliferation, invasion, metastasis, angiogenesis and chemoresistance, all hallmarks of aggressive cancer. AEG-1 mediates its oncogenic function predominantly by interacting with various protein complexes. AEG-1 acts as a scaffold protein, activating multiple protumorigenic signal transduction pathways, such as MEK/ERK, PI3K/Akt, NF-κB and Wnt/β-catenin while regulating gene expression at transcriptional, post-transcriptional and translational levels. Our recent studies document that AEG-1 is fundamentally required for activation of inflammation. A comprehensive and convincing body of data currently points to AEG-1 as an essential component critical to the onset and progression of cancer. The present review describes the current knowledge gleaned from patient and experimental studies as well as transgenic and knockout mouse models, on the impact of AEG-1 on hepatocarcinogenesis.

Indexed as

AEG-1angiogenesischemoresistancehepatocellular carcinomainflammationmetastasis

Identifiers

PMID26798451
PMCPMC4717832
OpenAlexW1924655001

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.