ArticleSkeletal muscle2016
Decrease of myofiber branching via muscle-specific expression of the olfactory receptor mOR23 in dystrophic muscle leads to protection against mechanical stress.
Article in Skeletal muscle, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Twisting Paths: The Paradox of Fiber Branching in Muscle Regeneration.International journal of molecular sciences · 2026Review
- Quantification of muscle fiber malformations using edge detection to investigate chronic muscle pressure ulcers.Frontiers in bioinformatics · 2024Article
- Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle.eLife · 2023Article
- The Implication of Hinge 1 and Hinge 4 in Micro-Dystrophin Gene Therapy for Duchenne Muscular Dystrophy.Human gene therapy · 2023Article
- Article
- Six weeks of N-acetylcysteine antioxidant in drinking water decreases pathological fiber branching in MDX mouse dystrophic fast-twitch skeletal muscle.Frontiers in physiology · 2023Article
- Loss of α-actinin-3 confers protection from eccentric contraction damage in fast-twitch EDL muscles from aged mdx dystrophic mice by reducing pathological fibre branching.Human molecular genetics · 2022Article
- Article
- Ectopic Odorant Receptor Responding to Flavor Compounds: Versatile Roles in Health and Disease.Pharmaceutics · 2021Review
- A Genome-Wide Association Study Identifies Novel Risk Loci for Sarcopenia in a Taiwanese Population.Journal of inflammation research · 2021Article
- Lifespan Analysis of DystrophicFrontiers in physiology · 2021Article
- Lifetime analysis of mdx skeletal muscle reveals a progressive pathology that leads to myofiber loss.Scientific reports · 2020Article
- A novel ex vivo protocol to mimic human walking gait: implications for Duchenne muscular dystrophy.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Comprehensive evaluation of the metabolic effects of insect meal fromJournal of animal science and biotechnology · 2020Article
- Muscle Fiber Splitting Is a Physiological Response to Extreme Loading in Animals.Exercise and sport sciences reviews · 2019Review
- Therapeutic potential of ectopic olfactory and taste receptors.Nature reviews. Drug discovery · 2019Review
- System-Wide Expression and Function of Olfactory Receptors in Mammals.Genomics & informatics · 2018Review
- Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue.Scientific reports · 2018Article
- Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense.Frontiers in physiology · 2018Review
- The breaking and making of healthy adult human skeletal muscle in vivo.Skeletal muscle · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAbnormal branched myofibers within skeletal muscles are commonly found in diverse animal models of muscular dystrophy as well as in patients. Branched myofibers from dystrophic mice are more susceptible to break than unbranched myofibers suggesting that muscles containing a high percentage of these myofibers are more prone to injury. Previous studies showed ubiquitous over-expression of mouse olfactory receptor 23 (mOR23), a G protein-coupled receptor, in wild type mice decreased myofiber branching. Whether mOR23 over-expression specifically in skeletal muscle cells is sufficient to mitigate myofiber branching in dystrophic muscle is unknown.
methodsWe created a novel transgenic mouse over-expressing mOR23 specifically in muscle cells and then bred with dystrophic (mdx) mice. Myofiber branching was analyzed in these two transgenic mice and membrane integrity was assessed by Evans blue dye fluorescence.
resultsmOR23 over-expression in muscle led to a decrease of myofiber branching after muscle regeneration in non-dystrophic mouse muscles and reduced the severity of myofiber branching in mdx mouse muscles. Muscles from mdx mouse over-expressing mOR23 significantly exhibited less damage to eccentric contractions than control mdx muscles.
conclusionsThe decrease of myofiber branching in mdx mouse muscles over-expressing mOR23 reduced the amount of membrane damage induced by mechanical stress. These results suggest that modifying myofiber branching in dystrophic patients, while not preventing degeneration, could be beneficial for mitigating some of the effects of the disease process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.