Evidence map›Paper›PMID 26798439›Full record

ReviewWorld journal of gastrointestinal oncology2016

Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer.

Gulcin Tezcan, Berrin Tunca, Secil Ak, Gulsah Cecener, Unal Egeli

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastrointestinal oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Advanced-Stage Colorectal Cancer in Persons Younger Than 50 Years Not Associated With Longer Duration of Symptoms or Time to Diagnosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2017
    Article
  10. Review
  11. Article
  12. Tumor suppressor genes in familial adenomatous polyposis.Gastroenterology and hepatology from bed to bench · 2017
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gulcin TezcanGulcin Tezcan, Berrin Tunca, Secil Ak, Gulsah Cecener, Unal Egeli, Department of Medical Biology, Faculty of Medicine, Uludag University, 16059 Bursa, Turkey.
Berrin TuncaGulcin Tezcan, Berrin Tunca, Secil Ak, Gulsah Cecener, Unal Egeli, Department of Medical Biology, Faculty of Medicine, Uludag University, 16059 Bursa, Turkey.
Secil AkGulcin Tezcan, Berrin Tunca, Secil Ak, Gulsah Cecener, Unal Egeli, Department of Medical Biology, Faculty of Medicine, Uludag University, 16059 Bursa, Turkey.
Gulsah CecenerGulcin Tezcan, Berrin Tunca, Secil Ak, Gulsah Cecener, Unal Egeli, Department of Medical Biology, Faculty of Medicine, Uludag University, 16059 Bursa, Turkey.
Unal EgeliGulcin Tezcan, Berrin Tunca, Secil Ak, Gulsah Cecener, Unal Egeli, Department of Medical Biology, Faculty of Medicine, Uludag University, 16059 Bursa, Turkey.
Bursa Uludağ Üni̇versi̇tesi̇ · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC (EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, MutYH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach.

Indexed as

Clinical outcomeColorectal cancerEarly-onsetEpigenetic mechanismGenetic mechanism

Identifiers

PMID26798439
PMCPMC4714149
OpenAlexW2406782586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.