ArticleOxidative medicine and cellular longevity2016
The Role of the Exo-Xis Region in Oxidative Stress-Mediated Induction of Shiga Toxin-Converting Prophages.
Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Complex effects of the exo-xis region of the Shiga toxin-converting bacteriophage Φ24Journal of applied genetics · 2024Article
- Molecular Modeling the Proteins from theAntibiotics (Basel, Switzerland) · 2021Review
- Article
- Ea22 Proteins from Lambda and Shiga Toxin-Producing Bacteriophages Balance Structural Diversity with Functional Similarity.ACS omega · 2020Article
- The ea22 gene of lambdoid phages: preserved prolysogenic function despite of high sequence diversity.Virus genes · 2020Article
- The Site-Specific Recombination System of theFrontiers in microbiology · 2020Article
- Inhibition of Shiga toxin-converting bacteriophage development by novel antioxidant compounds.Journal of enzyme inhibition and medicinal chemistry · 2018Article
- Roles ofViruses · 2018Article
- Bad Phages in Good Bacteria: Role of the MysteriousFrontiers in microbiology · 2017Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
Previous studies indicated that these genetic elements could be involved in the regulation of lysogenization and prophage induction processes. The effects were dramatic in Shiga toxin-converting phage Φ24(B) after treatment with oxidative stress-inducing agent, hydrogen peroxide, while they were less pronounced in bacteriophage λ and in both phages irradiated with UV. The hydrogen peroxide-caused prophage induction was found to be RecA-dependent. Importantly, in hydrogen peroxide-treated E. coli cells lysogenic for either λ or Φ24(B), deletion of the exo-xis region resulted in a significant decrease in the levels of expression of the S.O.S. regulon genes. Moreover, under these conditions, a dramatic decrease in the levels of expression of phage genes crucial for lytic development (particularly xis, exo, N, cro, O, Q, and R) could be observed in Φ24(B)-, but not in λ-bearing cells. We conclude that genes located in the exo-xis region are necessary for efficient expression of both host S.O.S regulon in lysogenic bacteria and regulatory genes of Shiga toxin-converting bacteriophage Φ24(B).
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