ArticleEvidence-based complementary and alternative medicine : eCAM2015
The Consumption of Bicarbonate-Rich Mineral Water Improves Glycemic Control.
Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04632277 (Daily Intake of Magnesium From Drinking Water in Relation to Diabetes Mellites), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Daily Intake of Magnesium From Drinking Water in Relation to Diabetes Mellites
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Prevention and Therapy of Type 2 Diabetes-What Is the Potential of Daily Water Intake and Its Mineral Nutrients?Nutrients · 2017Pooled it
- Lubiprostone in chronic kidney disease: Insights into mitochondrial function and polyamines from a randomized phase 2 clinical trial.Science advances · 2025Trial
- Trial
- The effect of drinking water pH on the human gut microbiota and glucose regulation: results of a randomized controlled cross-over intervention.Scientific reports · 2018Trial
- Association between bone marrow donor origin and gut microbiota composition following fecal microbiota transplantation in mice.Scientific reports · 2026Article
- Development of a monoclonal antibody-based approach for selective enrichment of targetGut microbes reports · 2026Article
- Beyond Thirst: Influence of Bicarbonate Mineral Water on Cardiovascular Risk Factors, Gastrointestinal Function, and Liver Health.Food science & nutrition · 2025Review
- Article
- Ecologically robust gut environment associated with personalized metabolic responses in a Japanese cohort.Gut microbes reports · 2025Article
- Associations between food consumption with T cell activation and antibody responses following SARS-CoV-2 mRNA vaccination.Gut microbes reports · 2025Article
- Myoban hot spring bathing improves gut microbiota composition and short-chain fatty acid levels: a pilot study.Environmental health and preventive medicine · 2025Article
- Evaluation of hydro-chemical facies and surface water quality dynamics using multivariate statistical approaches in Southern Nigeria.Scientific reports · 2024Article
- Barley β-glucan consumption improves glucose tolerance by increasing intestinal succinate concentrations.NPJ science of food · 2024Article
- Long-Term Consumption of Purified Water Altered Amino Acid, Fatty Acid and Energy Metabolism in Livers of Rats.Metabolites · 2024Article
- Natural Changbai mineral water reduces obesity risk through regulating metabolism and gut microbiome in a hyperuricemia male mouse model.Frontiers in nutrition · 2024Article
- The Effect ofDermatopathology (Basel, Switzerland) · 2023Article
- Article
- High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection.Nature communications · 2023Article
- Different Approaches to Ergogenic, Pre-, and Probiotic Supplementation in Sports with Different Metabolism Characteristics: A Mini Review.Nutrients · 2023Review
- Analysis of gut microbiotal diversity in healthy young adults in Sunan County, Gansu Province, China.Frontiers in cellular and infection microbiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hot spring water and natural mineral water have been therapeutically used to prevent or improve various diseases. Specifically, consumption of bicarbonate-rich mineral water (BMW) has been reported to prevent or improve type 2 diabetes (T2D) in humans. However, the molecular mechanisms of the beneficial effects behind mineral water consumption remain unclear. To elucidate the molecular level effects of BMW consumption on glycemic control, blood metabolome analysis and fecal microbiome analysis were applied to the BMW consumption test. During the study, 19 healthy volunteers drank 500 mL of commercially available tap water (TW) or BMW daily. TW consumption periods and BMW consumption periods lasted for a week each and this cycle was repeated twice. Biochemical tests indicated that serum glycoalbumin levels, one of the indexes of glycemic controls, decreased significantly after BMW consumption. Metabolome analysis of blood samples revealed that 19 metabolites including glycolysis-related metabolites and 3 amino acids were significantly different between TW and BMW consumption periods. Additionally, microbiome analysis demonstrated that composition of lean-inducible bacteria was increased after BMW consumption. Our results suggested that consumption of BMW has the possible potential to prevent and/or improve T2D through the alterations of host metabolism and gut microbiota composition.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.