ArticleAdvances in pharmacological sciences2015
Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profile of Three Medicinal Plants from Turkey.
Article in Advances in pharmacological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- First Report on the Phytochemical and Pharmacological Properties of Hedysarum yilmazunalii.Chemistry & biodiversity · 2026Article
- Organ-Specific Targeted Phenolic Profiling, Antioxidant, and Enzyme-Inhibitory Activities of the Gypsophilous EndemicMolecules (Basel, Switzerland) · 2026Article
- Extraction-dependent phenolic shifts drive antioxidant and multi-enzyme inhibitory activities of Onosma rechingeri methanolic extracts.Scientific reports · 2026Article
- Nutritional and Therapeutic Potential ofFood science & nutrition · 2025Article
- Investigating the optimisticHeliyon · 2024Article
- Phytochemical screening, HPLC fingerprinting andHeliyon · 2024Article
- Anti-Alzheimer's Potency of Rich Phenylethanoid Glycosides Extract fromPharmaceuticals (Basel, Switzerland) · 2024Article
- Species of the SectionsInternational journal of molecular sciences · 2024Review
- Above the Invasive and Ornamental Attributes of the Traveler's Palm: An In Vitro and In Silico Insight into the Anti-Oxidant, Anti-Enzymatic, Cytotoxic and Phytochemical Characterization ofAntioxidants (Basel, Switzerland) · 2023Article
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- Green synthesis of nanosized N,N'-bis(1-naphthylidene)-4,4'-diaminodiphenylmethane and its metal (II) complexes and evaluation of their biological activity.Scientific reports · 2022Article
- Tea and coffee polyphenols and their biological properties based on the latestIndustrial crops and products · 2022Review
- Chemical Composition, Anti-Quorum Sensing, Enzyme Inhibitory, and Antioxidant Properties of Phenolic Extracts ofPlants (Basel, Switzerland) · 2021Article
- Phytosomes as an Emerging Nanotechnology Platform for the Topical Delivery of Bioactive Phytochemicals.Pharmaceutics · 2021Review
- Middle East Medicinal Plants in the Treatment of Diabetes: A Review.Molecules (Basel, Switzerland) · 2021Review
- α-Amylase and α-glucosidase inhibitor effects and pancreatic response to diabetes mellitus on Wistar rats of Ephedra alata areal part decoction with immunohistochemical analyses.Environmental science and pollution research international · 2019Article
- In vitro inhibitory activities of selected Australian medicinal plant extracts against protein glycation, angiotensin converting enzyme (ACE) and digestive enzymes linked to type II diabetes.BMC complementary and alternative medicine · 2016Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We aimed to investigate the inhibitory potential of three medicinal plants (Hedysarum varium, Onobrychis hypargyrea, and Vicia truncatula) from Turkey against key enzymes involved in human pathologies, namely, diabetes (α-amylase and α-glucosidase), neurodegenerative disorders (tyrosinase, acetylcholinesterase, and butyrylcholinesterase), and hyperpigmentation (tyrosinase). The antioxidant potential, phenolic and flavonoid content of ethyl acetate, and methanolic and aqueous extracts were investigated using in vitro assays. The total antioxidant capacity (TAC), β-carotene/linoleic acid bleaching activity, 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH(•)), 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(•+)), cupric ion reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), and metal chelating activity on ferrous ions were used to evaluate the antioxidant capabilities of the extracts. The half-maximal inhibitory concentrations (IC50) of the extracts on cholinesterase, tyrosinase, and α-amylase were significantly higher than the references, galantamine, kojic acid, and acarbose, respectively. The half-maximal effective concentrations (EC50) of the extracts on TAC, CUPRAC, and FRAP were significantly higher than trolox. The phenol and flavonoid contents of the plant extracts were in the range 20.90 ± 0.190-83.25 ± 0.914 mg gallic acid equivalent/g extract and 1.45 ± 0.200-39.71 ± 0.092 mg rutin equivalent/g extract, respectively. The plants were found to possess moderate antioxidant capacities and interesting inhibitory action against key enzymes.
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