ArticleKorean journal of radiology
Quantitative Analysis of Disc Degeneration Using Axial T2 Mapping in a Percutaneous Annular Puncture Model in Rabbits.
Article in Korean journal of radiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Quantitative assessment of lumbar intervertebral disc degeneration and its correlation with clinical symptoms: a study utilizing ultrashort time-of-echo and T2 mapping as biomarkers.BMC musculoskeletal disorders · 2025Article
- Comparison of the efficacy of autologous Lp-PRP and Lr-PRP for treating intervertebral disc degeneration: in vitro and in vivo study.Journal of orthopaedic surgery and research · 2024Article
- Magnetic resonance imaging classification in a percutaneous needle injury rat model of intervertebral disc degeneration.Journal of orthopaedic surgery and research · 2024Article
- Induction of cervical disc degeneration and discogenic pain by low concentration Propionibacterium acnes infection: an in vivo animal study.Arthritis research & therapy · 2024Article
- Comparison of Ultrasound-Guided Percutaneous and Open Surgery Approaches in The Animal Model of Tumor Necrosis Factor-Alpha-Induced Disc Degeneration.Cell journal · 2023Article
- Percutaneous lumbar annular puncture: A rat model to study intervertebral disc degeneration and pain-related behavior.JOR spine · 2022Article
- Ultrashort time-to-echo T2* and T2* relaxometry for evaluation of lumbar disc degeneration: a comparative study.BMC musculoskeletal disorders · 2022Article
- Evaluation of intervertebral disc regeneration with injection of mesenchymal stem cells encapsulated in PEGDA-microcryogel delivery system using quantitative T2 mapping: a study in canines.American journal of translational research · 2019Article
- Quantitative MRI correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Correlation Between Expression of High Temperature Requirement Serine Protease A1 (HtrA1) in Nucleus Pulposus and T2 Value of Magnetic Resonance Imaging.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate T2 relaxation time change using axial T2 mapping in a rabbit degenerated disc model and determine the most correlated variable with histologic score among T2 relaxation time, disc height index, and Pfirrmann grade. MATERIALS AND
methodsDegenerated disc model was made in 4 lumbar discs of 11 rabbits (n = 44) by percutaneous annular puncture with various severities of an injury. Lumbar spine lateral radiograph, MR T2 sagittal scan and MR axial T2 mapping were obtained at baseline and 2 weeks and 4 weeks after the injury in 7 rabbits and at baseline and 2 weeks, 4 weeks, and 6 weeks after the injury in 4 rabbits. Generalized estimating equations were used for a longitudinal analysis of changes in T2 relaxation time in degenerated disc model. T2 relaxation time, disc height index and Pfirrmann grade were correlated with the histologic scoring of disc degeneration using Spearman's rho test.
resultsThere was a significant difference in T2 relaxation time between uninjured and injured discs after annular puncture. Progressive decrease in T2 relaxation time was observed in injured discs throughout the study period. Lower T2 relaxation time was observed in the more severely injured discs. T2 relaxation time showed the strongest inverse correlation with the histologic score among the variables investigated (r = -0.811, p < 0.001).
conclusionT2 relaxation time measured with axial T2 mapping in degenerated discs is a potential method to assess disc degeneration.
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