Evidence map›Paper›PMID 26798054›Full record

ArticleDrug safety2016

Social Media Listening for Routine Post-Marketing Safety Surveillance.

Gregory E Powell, Harry A Seifert, Tjark Reblin, Phil J Burstein, James Blowers, J Alan Menius, Jeffery L Painter, Michele Thomas, Carrie E Pierce, Harold W Rodriguez and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Drug safety, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
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  7. Review
  8. Pharmacovigilance in the digital age: gaining insight from social media data.Experimental biology and medicine (Maywood, N.J.) · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. [Utilizing social media data in post-market safety surveillance].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021
    Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gregory E PowellGlaxoSmithKline, 5 Moore Dr., Research Triangle Park, NC, 27709, USA. gregory.e.powell@gsk.com.
Harry A SeifertGlaxoSmithKline Vaccines, King of Prussia, PA, USA.
Tjark ReblinGlaxoSmithKline, Stockley Park, UK.
Phil J BursteinGlaxoSmithKline, King of Prussia, PA, USA.
James BlowersGlaxoSmithKline, 5 Moore Dr., Research Triangle Park, NC, 27709, USA.
J Alan MeniusGlaxoSmithKline, 5 Moore Dr., Research Triangle Park, NC, 27709, USA.
Jeffery L PainterGlaxoSmithKline, 5 Moore Dr., Research Triangle Park, NC, 27709, USA.
Michele ThomasBlue Zone Industries, Chester Springs, PA, USA.
Carrie E PierceEpidemico Inc., Boston, MA, USA.
Harold W RodriguezEpidemico Inc., Boston, MA, USA.
John S BrownsteinEpidemico Inc., Boston, MA, USA.
Clark C FreifeldEpidemico Inc., Boston, MA, USA.
Heidi G BellZero Chaos, Research Triangle Park, NC, USA.
Nabarun DasguptaEpidemico Inc., Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPost-marketing safety surveillance primarily relies on data from spontaneous adverse event reports, medical literature, and observational databases. Limitations of these data sources include potential under-reporting, lack of geographic diversity, and time lag between event occurrence and discovery. There is growing interest in exploring the use of social media ('social listening') to supplement established approaches for pharmacovigilance. Although social listening is commonly used for commercial purposes, there are only anecdotal reports of its use in pharmacovigilance. Health information posted online by patients is often publicly available, representing an untapped source of post-marketing safety data that could supplement data from existing sources.

objectivesThe objective of this paper is to describe one methodology that could help unlock the potential of social media for safety surveillance.

methodsA third-party vendor acquired 24 months of publicly available Facebook and Twitter data, then processed the data by standardizing drug names and vernacular symptoms, removing duplicates and noise, masking personally identifiable information, and adding supplemental data to facilitate the review process. The resulting dataset was analyzed for safety and benefit information.

resultsIn Twitter, a total of 6,441,679 Medical Dictionary for Regulatory Activities (MedDRA(®)) Preferred Terms (PTs) representing 702 individual PTs were discussed in the same post as a drug compared with 15,650,108 total PTs representing 946 individual PTs in Facebook. Further analysis revealed that 26 % of posts also contained benefit information.

conclusionSocial media listening is an important tool to augment post-marketing safety surveillance. Much work remains to determine best practices for using this rapidly evolving data source.

Indexed as

Adverse Drug Reaction Reporting SystemsSocial MediaDatabases, FactualDrug-Related Side Effects and Adverse ReactionsHumansInformation Storage and RetrievalPharmacovigilanceProduct Surveillance, PostmarketingResearch ReportSafety

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.