ArticleAging2016
Metabolomics profiling reveals novel markers for leukocyte telomere length.
Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Effects of Modified Attapulgite on Daily Weight Gain, Serum Indexes and Serum Metabolites in Fattening Beef Cattle.Animals : an open access journal from MDPI · 2025Article
- Serum phospholipids during aging: A comprehensive systematic review of cross-sectional and case-control studies.Health promotion perspectives · 2025Review
- The multi-omics signatures of telomere length in childhood.BMC genomics · 2025Article
- Telomere Length, HLA, and Longevity-Results from a Multicenter Study.International journal of molecular sciences · 2024Article
- Mendelian randomization analysis reveals causal associations of serum metabolites with sepsis and 28-day mortality.Scientific reports · 2024Article
- Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke.Journal of translational medicine · 2023Article
- Lipidomics profiling of biological aging in American Indians: the Strong Heart Family Study.GeroScience · 2023Article
- A time-series analysis of blood-based biomarkers within a 25-year longitudinal dolphin cohort.PLoS computational biology · 2023Article
- Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population.Hepatology communications · 2022Article
- Review
- Metabolic correlates of late midlife cognitive outcomes: findings from the 1946 British Birth Cohort.Brain communications · 2022Article
- Multi-Omics Approaches Revealed the Associations of Host Metabolism and Gut Microbiome With Phylogeny and Environmental Adaptation in Mountain Dragons.Frontiers in microbiology · 2022Article
- Serum gamma-glutamyl transferase, a marker of alcohol intake, is associated with telomere length and cardiometabolic risk in young adulthood.Scientific reports · 2021Article
- Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players.Frontiers in molecular biosciences · 2021Article
- Positive association and future perspectives of mitochondrial DNA copy number and telomere length - a pilot twin study.Archives of medical science : AMS · 2021Article
- A 25-y longitudinal dolphin cohort supports that long-lived individuals in same environment exhibit variation in aging rates.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Metabolism of sleep and aging: Bridging the gap using metabolomics.Nutrition and healthy aging · 2019Review
- Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium.Scientific reports · 2019Article
- Mitochondrial quality control mechanisms as molecular targets in cardiac ageing.Nature reviews. Cardiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 9 institutions in 4 countries.
Funding
Abstract
Leukocyte telomere length (LTL) is considered one of the most predictive markers of biological aging. The aim of this study was to identify novel pathways regulating LTL using a metabolomics approach. To this end, we tested associations between 280 blood metabolites and LTL in 3511 females from TwinsUK and replicated our results in the KORA cohort. We furthermore tested significant metabolites for associations with several aging-related phenotypes, gene expression markers and epigenetic markers to investigate potential underlying pathways. Five metabolites were associated with LTL: Two lysolipids, 1-stearoylglycerophosphoinositol (P=1.6×10(-5)) and 1-palmitoylglycerophosphoinositol (P=1.6×10(-5)), were found to be negatively associated with LTL and positively associated with phospholipase A2 expression levels suggesting an involvement of fatty acid metabolism and particularly membrane composition in biological aging. Moreover, two gamma-glutamyl amino acids, gamma-glutamyltyrosine (P=2.5×10(-6)) and gamma-glutamylphenylalanine (P=1.7×10(-5)), were negatively correlated with LTL. Both are products of the glutathione cycle and markers for increased oxidative stress. Metabolites were also correlated with functional measures of aging, i.e. higher blood pressure and HDL cholesterol levels and poorer lung, liver and kidney function. Our results suggest an involvement of altered fatty acid metabolism and increased oxidative stress in human biological aging, reflected by LTL and age-related phenotypes of vital organ systems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.