ReviewPain2016
Mesolimbic dopamine signaling in acute and chronic pain: implications for motivation, analgesia, and addiction.
Review in Pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
141 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Structural and Functional Neuroimaging Findings in Fibromyalgia: A Systematic Review.European journal of pain (London, England) · 2026Pooled it
- The association between pain, analgesia, and delirium among critically ill adults: a systematic review and meta-analysis.Intensive care medicine · 2025Pooled it
- Effects of Chronic Pain Treatment on Altered Functional and Metabolic Activities in the Brain: A Systematic Review and Meta-Analysis of Functional Neuroimaging Studies.Frontiers in neuroscience · 2021Pooled it
- Transcutaneous auricular nerve stimulation modulates the functional connectivity of the descending pain modulation system and reward network in patients with chronic low back pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Trial
- Dopamine has no direct causal role in the formation of treatment expectations and placebo analgesia in humans.PLoS biology · 2024Trial
- The functional role of opioidergic system within the ventral tegmental area and the dentate gyrus of hippocampus in modulation of the persistent inflammatory pain in the rats.IBRO neuroscience reports · 2026Article
- Conditioned Pain Modulation and Pleasant Pain Relief as Complementary Processes Reflecting Individual Differences in Pain Coping: A Clustering Approach.European journal of pain (London, England) · 2026Article
- Smoking Abstinence Elicits Hyperalgesia: Neural Mechanism, Clinical Implications, and Pharmacological Managements.CNS neuroscience & therapeutics · 2026Review
- Dopamine transporter gene (Pain reports · 2026Article
- Dynamic coupling of emotion and pain: from perception to affective response.The Korean journal of pain · 2026Review
- A brainstem pathway underlying vagal modulation of somatic pain and affective states.Nature neuroscience · 2026Article
- Chronic Pain and Opioids in the Elderly: Treating the Brain, Not Just the Body.International journal of environmental research and public health · 2026Review
- Reward Deficiency Syndrome (RDS): A Common Neurogenetic Trait/State of All Addictions: Is this the new DSM?British journal of healthcare and medical research · 2026Article
- Upregulation of NR2A in Glutamatergic VTA Neurons Contributes to Chronic Visceral Pain in Male Mice.Neuroscience bulletin · 2025Article
- Dysregulation of Hedonic Processing in Chronic Pain: Insights from Preclinical Data.Brain sciences · 2025Review
- Reduced SK channel control of mesolimbic dopamine neuron firing drives reward seeking adaptations in chronic pain.bioRxiv : the preprint server for biology · 2025Article
- Article
- Review
- Vestibulodynia presentation is differentiated by the presence of additional chronic primary pain conditions.The journal of pain · 2025Article
- Opioid Therapy in Chronic Pain: Assessment of Clinical Outcomes and Relationships With Endocrine Biomarkers.European journal of pain (London, England) · 2025Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.