Evidence map›Paper›PMID 26797597›Full record

ArticleMolecules (Basel, Switzerland)2016

Total Synthesis of Chiral Falcarindiol Analogues Using BINOL-Promoted Alkyne Addition to Aldehydes.

Li Wang, Ping-Ping Shou, Si-Ping Wei, Chun Zhang, Shuang-Xun Li, Ping-Xian Liu, Xi Du, Qin Wang

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li WangDepartment of Medicinal Chemistry, Sichuan Medical University, Luzhou 646000, China. liwang_512@163.com.
Ping-Ping ShouDepartment of Medicinal Chemistry, Sichuan Medical University, Luzhou 646000, China. sh362135508@163.com.
Si-Ping WeiDepartment of Medicinal Chemistry, Sichuan Medical University, Luzhou 646000, China. swei1225@gmail.com.
Chun ZhangDepartment of Medicinal Chemistry, Sichuan Medical University, Luzhou 646000, China. zc83good@126.com.
Shuang-Xun LiDepartment of Medicinal Chemistry, Sichuan Medical University, Luzhou 646000, China. 18183382321@sina.cn.
Ping-Xian LiuDepartment of Medicinal Chemistry, Sichuan Medical University, Luzhou 646000, China. bojizihan@sina.cn.
Xi DuDepartment of Medicinal Chemistry, Sichuan Medical University, Luzhou 646000, China. dx.d@163.com.
Qin WangDepartment of Medicinal Chemistry, Sichuan Medical University, Luzhou 646000, China. wq_ring@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An enantioselective total synthesis of chiral falcarindiol analogues from buta-1,3-diyn-1-yltriisopropylsilane is reported. The key step in this synthesis is BINOL-promoted asymmetric diacetylene addition to aldehydes. The two chiral centers of the falcarindiol analogues can be produced by using the same kind of catalyst with high selectivity, and the final product can be obtained in only six steps.

Indexed as

AldehydesAlkynesCatalysisDiynesEstersFatty AlcoholsMolecular StructureNaphtholsAldehydesAlkynesBINOL, naphtholDiynesEstersfalcarindiolFatty AlcoholsNaphtholsalkyneasymmetric additionBINOLdiynolfalcarindiol analoguestotal synthesis

Identifiers

PMID26797597
PMCPMC6274458

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.