ArticleNeurotoxicology2016
Fetal domoic acid exposure affects lateral amygdala neurons, diminishes social investigation and alters sensory-motor gating.
Article in Neurotoxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- The Toxic Effects of Environmental Domoic Acid Exposure on Humans and Marine Wildlife.Marine drugs · 2025Review
- Life Course Considerations in Environmental Health: Developmental Neurotoxicity of Domoic Acid at Doses Below Acute Effect Levels in Adult Humans.Birth defects research · 2024Review
- The symptomatology and diagnosis of domoic acid toxicosis in stranded California sea lions (Frontiers in veterinary science · 2023Article
- Public health risks associated with chronic, low-level domoic acid exposure: A review of the evidence.Pharmacology & therapeutics · 2021Review
- Developmental Exposure to Domoic Acid Disrupts Startle Response Behavior and Circuitry in Zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Developmental Neurotoxicity of the Harmful Algal Bloom Toxin Domoic Acid: Cellular and Molecular Mechanisms Underlying Altered Behavior in the Zebrafish Model.Environmental health perspectives · 2020Article
- Maternal-fetal disposition of domoic acid following repeated oral dosing during pregnancy in nonhuman primate.Toxicology and applied pharmacology · 2020Article
- Domoic acid in California sea lion fetal fluids indicates continuous exposure to a neuroteratogen poses risks to mammals.Harmful algae · 2018Article
- A single subconvulsant dose of domoic acid at mid-gestation does not cause temporal lobe epilepsy in mice.Neurotoxicology · 2018Article
- What California sea lions exposed to domoic acid might teach us about autism: lessons for predictive and preventive medicine.The EPMA journal · 2017Review
- Prenatal domoic acid exposure disrupts mouse pro-social behavior and functional connectivity MRI.Behavioural brain research · 2016Article
- Preclinical modeling of exposure to a global marine bio-contaminant: Effects of in utero Domoic acid exposure on neonatal behavior and infant memory.Neurotoxicology and teratologyArticle
- Effects of oral domoic acid exposure on maternal reproduction and infant birth characteristics in a preclinical nonhuman primate model.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Domoic acid (DA) is an algal neurotoxin that accumulates in marine fish and shellfish. DA can move across the placenta and concentrate in amniotic fluid, which can be swallowed during late gestation. DA also transfers to infants via milk. Preclinical studies to determine effects of developmental DA expose have primarily involved DA exposure during the postnatal period and little is known about late CNS effects following prenatal DA. In the present study, we tested the hypothesis that prenatal exposure of FVB mice to low levels of DA would result in diminished social interaction and sensory motor gating associated with alterations in parvalbumin immunoreactivity in relevant brain regions undergoing development during and following DA exposure. In addition to parvalbumin, we stained with NeuN for a neuronal specific nuclear protein to determine if neuronal loss followed prenatal DA exposure. A single moderate dose of DA administered during gestation produces diminishes social investigation and alters sensorimotor gating, behavioral effects more pronounced in males than females. These behavioral changes were associated with discrete alterations in the parvalbumin-positive subtype of GABAergic neurons in the dentate gyrus and lateral amygdala.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.