Evidence map›Paper›PMID 26797190›Full record

ArticleActa histochemica2016

Antioxidant diet and sex interact to regulate NOS isoform expression and glomerular mesangium proliferation in Zucker diabetic rat kidney.

Yuriy Slyvka, Ramiro Malgor, Sharon R Inman, Julia Ding, Victor Heh, Felicia V Nowak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta histochemica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Dual inhibition of cannabinoid CBBritish journal of pharmacology · 2020
    Article
  7. Article
  8. Sex differences in diabetes and kidney disease: mechanisms and consequences.American journal of physiology. Renal physiology · 2019
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuriy SlyvkaDepartment of Biomedical Sciences, Ohio University, Athens, OH 45701, USA; The Diabetes Institute at Ohio University, Ohio University, Athens, OH 45701, USA.
Ramiro MalgorDepartment of Biomedical Sciences, Ohio University, Athens, OH 45701, USA; Program in Molecular and Cellular Biology, Ohio University, Athens, OH 45701, USA; The Diabetes Institute at Ohio University, Ohio University, Athens, OH 45701, USA.
Sharon R InmanDepartment of Biomedical Sciences, Ohio University, Athens, OH 45701, USA; Program in Molecular and Cellular Biology, Ohio University, Athens, OH 45701, USA; The Diabetes Institute at Ohio University, Ohio University, Athens, OH 45701, USA.
Julia DingCollege of Natural Sciences, School of Biological Sciences, University of Texas at Austin, TX 78713, USA.
Victor HehOUHCOM Office of Research & Grants, Ohio University, Athens, OH 45701, USA.
Felicia V NowakDepartment of Biomedical Sciences, Ohio University, Athens, OH 45701, USA; Program in Molecular and Cellular Biology, Ohio University, Athens, OH 45701, USA; The Diabetes Institute at Ohio University, Ohio University, Athens, OH 45701, USA. Electronic address: nowak@ohio.edu.
Ohio University · USThe University of Texas at Austin · US

Funding

Antioxidants and Development of Diabetic NephropathyR15DK073066 · NIDDK · OHIO UNIVERSITY ATHENS · PI INMAN, SHARON RUTH · 2006 to 2007
$217k
NIDDK NIH HHS R15 DK073066NIDDK NIH HHS R15DK073066
6 · The paper itself

Abstract

Oxidative stress contributes substantially to the pathophysiology of diabetic nephropathy (DN). Consumption of an antioxidant-fortified (AO) diet from an early age prevents or delays later development of DN in the Zucker rat female with type 2 diabetes. We hypothesize this is due to effects on mesangial matrix and renal nitric oxide synthase (NOS) distribution and to sex-specific differences in NOS responses in the diabetic kidney. Total glomerular tuft area (GTA) and PAS-positive tuft area (PTA), endothelial (e), neuronal (n) and inducible (i) NOS were quantified in males and females on AO or regular (REG) diet at 6 and 20 weeks of age. eNOS was observed in glomeruli and tubules. nNOS predominantly localized to tubular epithelium in both cortex and medulla. iNOS was expressed in proximal and distal tubules and collecting ducts. Sex, diabetes duration and AO diet affected the distribution of the three isoforms. GTA and PTA increased with duration of hyperglycemia and showed a negative correlation with renal levels of all NOS isoforms. AO diet in both genders was associated with less PAS-positive staining and less mesangial expansion than the REG diet, an early increase in cortical iNOS in males, and sex-specific changes in cortical eNOS at 20 weeks. These effects of AO diet may contribute to sex-specific preservation of renal function in females.

Indexed as

Administration, OralAnimalsAntioxidantsDiabetes Mellitus, Type 2Diabetic NephropathiesDietFemaleIsoenzymesKidney GlomerulusMaleMesangial CellsNitric Oxide Synthase Type INitric Oxide Synthase Type IINitric Oxide Synthase Type IIIRats, ZuckerSex CharacteristicsAntioxidantsIsoenzymesNitric Oxide Synthase Type INitric Oxide Synthase Type IINitric Oxide Synthase Type IIINos2 protein, ratNos3 protein, ratAntioxidant dietDiabetic nephropathyMesangial matrixNitric oxide synthasesObesitySex difference

Identifiers

PMID26797190
PMCPMC4755810
OpenAlexW2250443404

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.