Trial reportAJNR. American journal of neuroradiology2016
Clinical Feasibility of Synthetic MRI in Multiple Sclerosis: A Diagnostic and Volumetric Validation Study.
Trial report in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Commercial volumetric MRI reporting tools in multiple sclerosis: a systematic review of the evidence.Neuroradiology · 2023Pooled it
- Technical and clinical validation of commercial automated volumetric MRI tools for dementia diagnosis-a systematic review.Neuroradiology · 2021Pooled it
- Long-term clinical and biomarker observations following rituximab exposure in two siblings with CSF1R-related leukoencephalopathy: a preliminary familial case series.Communications medicine · 2026Article
- Synthetic MRI and radiomics in multiple sclerosis: improving precision in diagnosis and prognosis.Radiological physics and technology · 2026Review
- Pathological signatures of white matter lesions in multiple sclerosis versus stroke: a synthetic MRI study.Neuroradiology · 2026Article
- Multimodal Quantitative MRI of White and Gray Matter: Associations with Myelin-Related Metrics in the Healthy Adult Brain Using Synthetic MRI and IVIM-DWI.Journal of clinical medicine · 2026Article
- Delta Histogram Analysis of Synthetic MRI for Evaluating Grade and Cellular Proliferation of Meningioma.Radiology. Imaging cancer · 2026Article
- Semi-supervision for clinical contrast-weighted image synthesis from magnetic resonance fingerprinting.Magma (New York, N.Y.) · 2026Article
- Clinical Image Quality and Reader Variability in 3D Synthetic Brain MRI Compared with Conventional MRI.Tomography (Ann Arbor, Mich.) · 2026Article
- Effect of Slice Thickness Variations on Knee Cartilage Quantification Using Magnetic Resonance Image Compilation SequencCurrent medical imaging · 2026Article
- Optimization of the Data Pattern and Analysis Algorithm for the T2-based Water Suppression Diffusion MRImaging (T2wsup-dMRI) Technique.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Characterizing Protein Concentration in Cerebrospinal Fluid with TMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Neuroimaging Reader Study on Clinical Sensitivity and Specificity Using Synthetic MRI Based on MR Quantification.AJNR. American journal of neuroradiology · 2025Article
- Technical aspects and clinical applications of synthetic MRI: a scoping review.Diagnosis (Berlin, Germany) · 2025Article
- Synthetic MRI in Progressive MS: Associations with Disability.AJNR. American journal of neuroradiology · 2025Article
- Synthetic MR: Clinical applications in neuroradiology.Neuroradiology · 2025Review
- Comparison of Syn T2-FLAIR and Syn DIR with conventional T2-FLAIR in displaying white matter hyperintensities in migraine patients.Neuroradiology · 2025Article
- Tyro3 and Gas6 are associated with white matter and myelin integrity in multiple sclerosis.Journal of neuroinflammation · 2024Article
- Improving the lesion appearance on FLAIR images synthetized from quantitative MRI: a fast, hybrid approach.Magma (New York, N.Y.) · 2024Article
- Ultrafast Brain MRI at 3 T for MS: Evaluation of a 51-Second Deep Learning-Enhanced T2-EPI-FLAIR Sequence.Diagnostics (Basel, Switzerland) · 2024Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeQuantitative MR imaging techniques are gaining interest as methods of reducing acquisition times while additionally providing robust measurements. This study aimed to implement a synthetic MR imaging method on a new scanner type and to compare its diagnostic accuracy and volumetry with conventional MR imaging in patients with MS and controls. MATERIALS AND
methodsTwenty patients with MS and 20 healthy controls were enrolled after ethics approval and written informed consent. Synthetic MR imaging was implemented on a Siemens 3T scanner. Comparable conventional and synthetic proton-density-, T1-, and T2-weighted, and FLAIR images were acquired. Diagnostic accuracy, lesion detection, and artifacts were assessed by blinded neuroradiologic evaluation, and contrast-to-noise ratios, by manual tracing. Volumetry was performed with synthetic MR imaging, FreeSurfer, FMRIB Software Library, and Statistical Parametric Mapping. Repeatability was quantified by using the coefficient of variance.
resultsSynthetic proton-density-, T1-, and T2-weighted images were of sufficient or good quality and were acquired in 7% less time than with conventional MR imaging. Synthetic FLAIR images were degraded by artifacts. Lesion counts and volumes were higher in synthetic MR imaging due to differences in the contrast of dirty-appearing WM but did not affect the radiologic diagnostic classification or lesion topography (P = .50-.77). Synthetic MR imaging provided segmentations with the shortest processing time (16 seconds) and the lowest repeatability error for brain volume (0.14%), intracranial volume (0.12%), brain parenchymal fraction (0.14%), and GM fraction (0.56%).
conclusionsSynthetic MR imaging can be an alternative to conventional MR imaging for generating diagnostic proton-density-, T1-, and T2-weighted images in patients with MS and controls while additionally delivering fast and robust volumetric measurements suitable for MS studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.