ArticleThe American journal of pathology2016
Molecular Genetic Analysis of Ovarian Brenner Tumors and Associated Mucinous Epithelial Neoplasms: High Variant Concordance and Identification of Mutually Exclusive RAS Driver Mutations and MYC Amplification.
Article in The American journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Mucinous Ovarian Carcinoma: Integrating Molecular Stratification into Surgical and Therapeutic Management.Biomedicines · 2025Review
- Cellular origins of mucinous ovarian carcinoma.The Journal of pathology · 2025Review
- Benign Brenner tumor of the ovary: two-dimensional and contrast-enhanced ultrasound features-a retrospective study from a single center.Frontiers in oncology · 2024Article
- Review
- Coexistence of a huge Brenner's tumour and mucinous cystadenoma in a 62-year-old female: a case report from Syria.Annals of medicine and surgery (2012) · 2023Article
- Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature.Medical sciences (Basel, Switzerland) · 2023Review
- Coexistence of malignant ovarian Brenner tumor and borderline mucinous cystadenoma, combined with primary uterine corpus endometrioid carcinoma: A case report and literature review.Oncology letters · 2022Article
- Living the best of both worlds: A personal scientific journey.FASEB bioAdvances · 2022Article
- Two types of primary mucinous ovarian tumors can be distinguished based on their origin.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Coexistence of Benign Brenner Tumor with Mucinous Cystadenoma in an Ovarian Mass.Iranian journal of pathology · 2020Article
- Article
- Ovarian mucinous cystic tumor associated with sarcomatous mural nodule and benign Brenner tumor: A case report and literature review.Medicine · 2019Review
- Distinct methylation profile of mucinous ovarian carcinoma reveals susceptibility to proteasome inhibitors.International journal of cancer · 2018Article
- Recent Insights into Mucinous Ovarian Carcinoma.International journal of molecular sciences · 2018Review
- Potential signaling pathways as therapeutic targets for overcoming chemoresistance in mucinous ovarian cancer.Biomedical reports · 2018Article
- Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells.Medicines (Basel, Switzerland) · 2018Review
- When Is "Type I" Ovarian Cancer Not "Type I"? Indications of an Out-Dated Dichotomy.Frontiers in oncology · 2018Review
- Functional and evolutionary analysis of Korean bob-tailed native dog using whole-genome sequencing data.Scientific reports · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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Abstract
Benign ovarian Brenner tumors often are associated with mucinous cystic neoplasms, which are hypothesized to share a histogenic origin and progression, however, supporting molecular characterization is limited. Our goal was to identify molecular mechanisms linking these tumors. DNA from six Brenner tumors with paired mucinous tumors, two Brenner tumors not associated with a mucinous neoplasm, and two atypical proliferative (borderline) Brenner tumors was extracted from formalin-fixed, paraffin-embedded tumor samples and sequenced using a 358-gene next-generation sequencing assay. Variant calls were compared within tumor groups to assess somatic mutation profiles. There was high concordance of the variants between paired samples (40% to 75%; P < 0.0001). Four of the six tumor pairs showed KRAS hotspot driver mutations specifically in the mucinous tumor. In the two paired samples that lacked KRAS mutations, MYC amplification was detected in both of the mucinous and the Brenner components; MYC amplification also was detected in a third Brenner tumor. Five of the Brenner tumors had no reportable potential driver alterations. The two atypical proliferative (borderline) Brenner tumors both had RAS mutations. The high degree of coordinate variants between paired Brenner and mucinous tumors supports a shared origin or progression. Differences observed in affected genes and pathways, particularly involving RAS and MYC, may point to molecular drivers of a divergent phenotype and progression of these tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.