Evidence map›Paper›PMID 26796948›Full record

ArticlePhysics in medicine and biology2016

Using edge-preserving algorithm with non-local mean for significantly improved image-domain material decomposition in dual-energy CT.

Wei Zhao, Tianye Niu, Lei Xing, Yaoqin Xie, Guanglei Xiong, Kimberly Elmore, Jun Zhu, Luyao Wang, James K Min

Registry-linked trialAbstract read
In one paragraph

Article in Physics in medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01825213 (Stratification of Patients With Chronic Liver Disease Using Multi Spectral CT), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01825213 completednot on this map

Stratification of Patients With Chronic Liver Disease Using Multi Spectral CT

TypeobservationalSponsorMassachusetts General HospitalRan2013 to 2016Enrolled10ConditionsChronic Liver Disease, HepatoCellular Carcinoma, Liver FibrosisArmsMultispectral CT of the liver
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Multi-Material Decomposition Using Spectral Diffusion Posterior Sampling.IEEE transactions on bio-medical engineering · 2025
    Article
  4. Article
  5. Article
  6. Image-domain Material Decomposition for Spectral CT using a Generalized Dictionary Learning.IEEE transactions on radiation and plasma medical sciences · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei ZhaoDepartment of Biomedical Engineering, Huazhong University of Science and Technology, Hubei 430074, People's Republic of China.
Tianye NiuSir Run Run Shaw Hospital, Zhejiang University School of Medicine; Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, People's Republic of China.
Lei XingDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Yaoqin XieShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, People's Republic of China.
Guanglei XiongDalio Institute of Cardiovascular Imaging New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY 10021, USA.
Kimberly ElmoreDalio Institute of Cardiovascular Imaging New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY 10021, USA.
Jun ZhuDepartment of Biomedical Engineering, Huazhong University of Science and Technology, Hubei 430074, People's Republic of China.
Luyao WangDepartment of Biomedical Engineering, Huazhong University of Science and Technology, Hubei 430074, People's Republic of China.
James K MinDalio Institute of Cardiovascular Imaging New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY 10021, USA.

Funding

Dual Energy Computed Tomography for Determining Coronary Lesion-Specific IschemiaR01HL111141 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI EDIC, PETER, MIN, JAMES K · 2013 to 2017
$3.0M
Computational Tools for Next Generation Volumetric Cone Beam Computed TomographyR01EB016777 · NIBIB · STANFORD UNIVERSITY · PI XING, LEI · 2013 to 2016
$2.1M
NHLBI NIH HHS 7R01HL111141NHLBI NIH HHS R01 HL111141NIBIB NIH HHS 1R01-EB016777NIBIB NIH HHS R01 EB016777
6 · The paper itself

Abstract

Increased noise is a general concern for dual-energy material decomposition. Here, we develop an image-domain material decomposition algorithm for dual-energy CT (DECT) by incorporating an edge-preserving filter into the Local HighlY constrained backPRojection reconstruction (HYPR-LR) framework. With effective use of the non-local mean, the proposed algorithm, which is referred to as HYPR-NLM, reduces the noise in dual-energy decomposition while preserving the accuracy of quantitative measurement and spatial resolution of the material-specific dual-energy images. We demonstrate the noise reduction and resolution preservation of the algorithm with an iodine concentrate numerical phantom by comparing the HYPR-NLM algorithm to the direct matrix inversion, HYPR-LR and iterative image-domain material decomposition (Iter-DECT). We also show the superior performance of the HYPR-NLM over the existing methods by using two sets of cardiac perfusing imaging data. The DECT material decomposition comparison study shows that all four algorithms yield acceptable quantitative measurements of iodine concentrate. Direct matrix inversion yields the highest noise level, followed by HYPR-LR and Iter-DECT. HYPR-NLM in an iterative formulation significantly reduces image noise and the image noise is comparable to or even lower than that generated using Iter-DECT. For the HYPR-NLM method, there are marginal edge effects in the difference image, suggesting the high-frequency details are well preserved. In addition, when the search window size increases from to , there are no significant changes or marginal edge effects in the HYPR-NLM difference images. The reference drawn from the comparison study includes: (1) HYPR-NLM significantly reduces the DECT material decomposition noise while preserving quantitative measurements and high-frequency edge information, and (2) HYPR-NLM is robust with respect to parameter selection.

Indexed as

AlgorithmsPhantoms, ImagingTomography, X-Ray Computed

Identifiers

PMID26796948
PMCPMC12333447

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.