Observational studyArchives of gynecology and obstetrics2016
Two-year outcome after recurrent first trimester miscarriages: prognostic value of the past obstetric history.
Observational study in Archives of gynecology and obstetrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Recurrent pregnancy loss: diagnostic workup after two or three pregnancy losses? A systematic review of the literature and meta-analysis.Human reproduction update · 2020Pooled it
- Reproductive factors and subsequent pregnancy outcomes in patients with prior pregnancy loss.BMC pregnancy and childbirth · 2024Trial
- Predicting risk of the subsequent early pregnancy loss in women with recurrent pregnancy loss based on preconception data.BMC women's health · 2024Article
- Endometrial thickness and early pregnancy complications after frozen-thawed embryo transfers.Frontiers in endocrinology · 2023Article
- Observational
- The association between miscarriage and fecundability: the Norwegian Mother, Father and Child Cohort Study.Human reproduction (Oxford, England) · 2022Article
- Recurrent pregnancy loss.Nature reviews. Disease primers · 2020Review
- Evaluation of etiology and pregnancy outcome in recurrent miscarriage patients.Saudi journal of biological sciences · 2020Article
- Comprehensive analysis of the associations between previous pregnancy failures and blastocyst aneuploidy as well as pregnancy outcomes after PGT-A.Journal of assisted reproduction and genetics · 2020Article
- Does anti-Mullerian hormone predict the outcome of further pregnancies in idiopathic recurrent miscarriage? A retrospective cohort study.Archives of gynecology and obstetrics · 2019Article
- Uterine Radial Artery Resistance Index Predicts Reproductive Outcome in Women with Recurrent Pregnancy Losses and Thrombophilia.BioMed research international · 2019Article
- Fertility after recurrent miscarriages: results of an observational cohort study.Archives of gynecology and obstetrics · 2018Article
- Association between G1733A (rs6152) polymorphism in androgen receptor gene and recurrent spontaneous abortions in Mexican population.Journal of assisted reproduction and genetics · 2017Article
- Recurrent pregnancy loss: current perspectives.International journal of women's health · 2017Review
- Current opportunities and new horizons into the genetic study of infertility.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
- First-trimester Doppler Ultrasound for Predicting Successful Management of Pregnancy with Recurrent Pregnancy Losses Due to Antiphospholipid Syndrome and Thrombophilia: A Cohort Study.Journal of human reproductive sciencesArticle
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRecurrent miscarriage (RM) is a stressful condition which gives rise to extensive diagnostic evaluation and is seen as a potentially curable maternal disease. Nevertheless, epidemiological data have shown that outcome is related to fertility. In addition to maternal age and number of preceding miscarriages, further markers derived from the past history may support counselling.
methodsObservational trial comprising 228 couples who were referred between 1996 and 2003 for immunological evaluation at maternal ages 20-39 years after three or more spontaneously conceived primary first trimester miscarriages. They were interviewed in 2005, ongoing pregnancies were followed up until birth in 2006. Past obstetric history was correlated with 2 year cumulative pregnancy and delivery rates (CPR, CDR).
resultsCPR and CDR were 206/228 (90.4 %) and 174/228 (76.4 %). Duration of infertility was associated with lower CPR (up to 3/>3 years, p < 0.01), whereas age and number of preceding losses inversely correlated with CDR (<35 years/35-39 years, p < 0.002; 3/>3 miscarriages, p < 0.002). Detection of an embryonic heart beat in 2-3 of the first three miscarriages resulted in favourable outcome (CPR: p < 0.02, CDR: p < 0.002). Prognosis was excellent in younger fertile women after three miscarriages where vital signs had been detected; under less favourable conditions not only risks for further miscarriage, but also for secondary infertility were elevated.
conclusionSecondary infertility is a feature of RM. Embryonic vital signs in preceding pregnancies are prognostic markers and should be regarded as a strong confounding factor in trials on therapeutic interventions. Prevention may be more appropriate than treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.