ArticleMolecular biology and evolution2016
Gap Gene Regulatory Dynamics Evolve along a Genotype Network.
Article in Molecular biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- System drift in the evolution of plant meristem development.PLoS genetics · 2026Article
- Genomic resources for the scuttle fly Megaselia abdita: a model organism for comparative developmental studies in flies.Development (Cambridge, England) · 2025Article
- Evolvability in vertebrate segmentation.Seminars in cell & developmental biology · 2025Review
- Understanding developmental system drift.Development (Cambridge, England) · 2024Review
- Approximated gene expression trajectories for gene regulatory network inference on cell tracks.iScience · 2024Article
- Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks.Science advances · 2023Article
- Robustness and innovation in synthetic genotype networks.Nature communications · 2023Article
- Article
- Using phenotypic plasticity to understand the structure and evolution of the genotype-phenotype map.Genetica · 2022Review
- Latent space of a small genetic network: Geometry of dynamics and information.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- In preprints: the problem of producing precise patterns.Development (Cambridge, England) · 2022Article
- Article
- System drift and speciation.Evolution; international journal of organic evolution · 2022Article
- The neuroblast timer gene nubbin exhibits functional redundancy with gap genes to regulate segment identity in Tribolium.Development (Cambridge, England) · 2021Article
- Time and space in segmentation.Interface focus · 2021Article
- Homology of process: developmental dynamics in comparative biology.Interface focus · 2021Article
- Article
- Biophysics and population size constrains speciation in an evolutionary model of developmental system drift.PLoS computational biology · 2019Article
- Article
- Novel approach to quantitative spatial gene expression uncovers genetic stochasticity in the developing Drosophila eye.Evolution & development · 2019Article
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4 authors.
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Abstract
Developmental gene networks implement the dynamic regulatory mechanisms that pattern and shape the organism. Over evolutionary time, the wiring of these networks changes, yet the patterning outcome is often preserved, a phenomenon known as "system drift." System drift is illustrated by the gap gene network-involved in segmental patterning-in dipteran insects. In the classic model organism Drosophila melanogaster and the nonmodel scuttle fly Megaselia abdita, early activation and placement of gap gene expression domains show significant quantitative differences, yet the final patterning output of the system is essentially identical in both species. In this detailed modeling analysis of system drift, we use gene circuits which are fit to quantitative gap gene expression data in M. abdita and compare them with an equivalent set of models from D. melanogaster. The results of this comparative analysis show precisely how compensatory regulatory mechanisms achieve equivalent final patterns in both species. We discuss the larger implications of the work in terms of "genotype networks" and the ways in which the structure of regulatory networks can influence patterns of evolutionary change (evolvability).
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