ArticleJournal of the American Heart Association2016
Stroke Severity Is a Crucial Predictor of Outcome: An International Prospective Validation Study.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
129 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Risk factors of stroke-related sarcopenia: a systematic review and meta-analysis.Frontiers in aging · 2025Pooled it
- The effect of time spent in rehabilitation on activity limitation and impairment after stroke.The Cochrane database of systematic reviews · 2021Pooled it
- Stroke Severity in Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement: A Systematic Review and Meta-Analysis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021Pooled it
- The effect of angiopoietin-1 upregulation on the outcome of acute ischaemic stroke in rodent models: A meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Pooled it
- Plasma choline and betaine and neurological function trajectory after acute ischemic stroke.BMC neurology · 2026Trial
- Trial
- Effects of an assist-as-needed equipped Tenodesis-Induced-Grip Exoskeleton Robot (TIGER) on upper limb function in patients with chronic stroke.Journal of neuroengineering and rehabilitation · 2024Trial
- Feasibility of a Clinical-Radiomics Model to Predict the Outcomes of Acute Ischemic Stroke.Korean journal of radiology · 2022Trial
- Trial
- Prediction of death after endovascular thrombectomy in the extended window: a secondary analysis of DEFUSE 3 ".Journal of neurointerventional surgery · 2021Trial
- Biological Age is a predictor of mortality in Ischemic Stroke.Scientific reports · 2018Trial
- A prediction model for functional outcome following rescue therapy in patients with acute ischemic stroke undergoing endovascular treatment.Annals of medicine · 2026Article
- Routine C-Reactive Protein on Admission and In-Hospital Outcomes in Acute Ischemic Stroke Patients Treated with Thrombectomy: A Retrospective Single-Center Study.Medicina (Kaunas, Lithuania) · 2026Article
- Review and Meta-Analyses of the Effects of MLC601/MLC901 (NeuroAiD) on Post-Stroke Functional and Motor Recovery.Neurology international · 2026Review
- Cardiac dysfunction after acute ischaemic stroke: Long-term outcomes from the SICFAIL cohort.International journal of cardiology. Heart & vasculature · 2026Article
- Predicting post-stroke functional outcome using explainable machine learning and integrated data.Scientific reports · 2026Article
- Ischemic Stroke Incidence and Severity and Poststroke Cognitive Decline and Incident Dementia.JAMA network open · 2026Article
- Performance of Modified NIHSS and APUA Scores in Predicting in-Hospital Mortality and Functional Outcome in Acute Ischemic Stroke: A Retrospective Cohort Study.Medeniyet medical journal · 2026Article
- Article
- Surface EMG-Validated Multi-DoF Wheelchair-Based Rehabilitation Device.Bioengineering (Basel, Switzerland) · 2026Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundStroke is among the leading causes of morbidity and mortality worldwide. Without reliable prediction models and outcome measurements, comparison of care systems is impossible. We analyzed prospectively collected data from 4 countries to explore the importance of stroke severity in outcome prediction. METHODS AND
resultsFor 2 months, all acute ischemic stroke patients from the hospitals participating in the Global Comparators Stroke GOAL (Global Outcomes Accelerated Learning) collaboration received a National Institutes of Health Stroke Scale (NIHSS) score on admission and a modified Rankin Scale score at 30 and 90 days. These data were added to the administrative data set, and risk prediction models including age, sex, comorbidity index, and NIHSS were derived for in-hospital death within 7 days, all in-hospital death, and death and good outcome at 30 and 90 days. The relative importance of each variable was assessed using the proportion of explained variation. Of 1034 admissions for acute ischemic stroke, 614 had a full set of NIHSS and both modified Rankin Scale values recorded; of these, 507 patients could be linked to administrative data. The marginal proportion of explained variation was 0.7% to 4.0% for comorbidity index, and 11.3 to 25.0 for NIHSS score. The percentage explained by the model varied by outcome (16.6-29.1%) and was highest for good outcome at 30 and 90 days. There was high agreement between 30- and 90-day modified Rankin Scale scores (weighted κ=0.82).
conclusionsIn this prospective pilot study, the baseline NIHSS score was essential for prediction of acute ischemic stroke outcomes, followed by age; whereas traditional comorbidity index contributed little to the overall model. Future studies of stroke outcomes between different care systems will benefit from including a baseline NIHSS score.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.