Evidence map›Paper›PMID 26795628›Full record

ReviewWiener medizinische Wochenschrift (1946)2016

[Genomwide association studies on obesity: what can we learn from these studies].

Florian Kronenberg, Bernhard Paulweber, Claudia Lamina

Open access · hybridAbstract readReview
PubMed Publisher
In one paragraph

Review in Wiener medizinische Wochenschrift (1946), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Observational
  3. [Not Available].Wiener medizinische Wochenschrift (1946) · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Florian KronenbergDivision für Genetische Epidemiologie, Department für Medizinische Genetik, Molekulare and Klinische Pharmakologie, Medizinische Universität Innsbruck, Schöpfstr. 41, 6020, Innsbruck, Österreich. Florian.Kronenberg@i-med.ac.at.
Bernhard PaulweberUniversitätsklinik für Innere Medizin I der Paracelsus Medizinischen Privatuniversität Salzburg, St. Johanns-Spital, Müllner Hauptstraße 48, 5020, Salzburg, Österreich.
Claudia LaminaDivision für Genetische Epidemiologie, Department für Medizinische Genetik, Molekulare and Klinische Pharmakologie, Medizinische Universität Innsbruck, Schöpfstr. 41, 6020, Innsbruck, Österreich.
Innsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The introduction of genome-wide association studies resulted in a tremendous increase in the number of genes associated with obesity and related phenotypes (BMI, waist and waist-hip-ratio). Despite this enormous gain in knowledge the search for genes is only started since only a small fraction of the heritability of these phenotypes is explained yet: each single gene of the 97 hitherto known BMI-associated genes and 49 waist-hip-ratio-associated genes explains only a tiny fraction of the variance of these phenotypes. Sex-specific differences are mainly known for waist-hip-ratio and ̴40% of the genes showed only an effect in women but no or a markedly smaller effect in men. The functional characterization of the identified genes will take a lot of time. It is unclear whether and how fast the findings will result in therapeutic consequences. It is of utmost importance that we understand the involved mechanisms before new therapeutic strategies can be developed.

Indexed as

Genome-Wide Association StudyBody Mass IndexFemaleGenetic Predisposition to DiseaseHumansMaleObesityPhenotypeSex CharacteristicsWaist-Hip RatioBody-Mass-IndexGenetic variabilityGenome-wide association studyHeritabilityObesityWaist-hip-ratio

Identifiers

PMID26795628
OpenAlexW2266702569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.