Evidence map›Paper›PMID 26795624›Full record

ArticleClinical oral investigations2016

Role of microcracks in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw.

Jin-Woo Kim, Maria Erika A Landayan, Ju-Young Lee, Jacquiline Czar I Tatad, Sun-Jong Kim, Myung-Rae Kim, In-Ho Cha

Abstract read
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Article in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jin-Woo KimGraduate School of Clinical Implant Dentistry, Ewha Womans University, Seoul, South Korea.
Maria Erika A LandayanGraduate School of Clinical Implant Dentistry, Ewha Womans University, Seoul, South Korea.
Ju-Young LeeGraduate School of Clinical Implant Dentistry, Ewha Womans University, Seoul, South Korea.
Jacquiline Czar I TatadGraduate School of Clinical Implant Dentistry, Ewha Womans University, Seoul, South Korea.
Sun-Jong KimGraduate School of Clinical Implant Dentistry, Ewha Womans University, Seoul, South Korea. oralsurgeonsj@gmail.com.ORCID http://orcid.org/0000-0003-2347-3516
Myung-Rae KimGraduate School of Clinical Implant Dentistry, Ewha Womans University, Seoul, South Korea.
In-Ho ChaDepartment of Oral and Maxillofacial Surgery, Yonsei University, Seoul, South Korea.
Ewha Womans University · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to investigate the potential role of microcrack accumulation in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (ONJ) through an animal model. MATERIALS AND

methodsTwenty-four ovariectomized rats were randomly divided into a bisphosphonate group (n = 19) and control group (n = 5) and weekly injected with zoledronic acid and normal saline, respectively. After 6 weeks, surgical intervention was performed, and the injections were continued for eight additional weeks. Then, the animals were sacrificed, and ONJ lesions were inspected for the presence of microcracks using scanning electron microscopy. Measurements included bone dimension, number of cracks, crack length, and normalized indices; crack density (Cr.Dn) and crack surface density (Cr.S.Dn) were used for group comparison.

resultsBoth number of cracks and crack length in the bisphosphonate group were greater than those in the control group (P < 0.05). Of the 19 rats injected with bisphosphonates, 13 rats (68.4 %) were classified into the ONJ group. Cr.Dn and Cr.S.Dn were significantly greater in the ONJ group than in the non-ONJ group, indicating accumulation of unrepaired microcracks (P < 0.05). Seventy-two percent of microcracks in the ONJ group conformed to the defined length that was considered significant according to a previous literature (30-80 μm); whereas 12 % of microcracks in the non-ONJ group were considered significant (P < 0.05).

conclusionAccumulation of unrepaired microcracks was significantly associated with the development of bisphosphonate-related ONJ. Further research is required to determine the role of microcracks in the pathogenesis of bisphosphonate-related ONJ. CLINICAL RELEVANCE: Long-term bisphosphonates use may deteriorate the biomechanical and physiological bone integrity, contributing to the pathogenesis of bisphosphonate-related ONJ.

Indexed as

AnimalsBisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsDiphosphonatesDisease Models, AnimalFemaleImidazolesJaw DiseasesMicroscopy, Electron, ScanningOvariectomyRandom AllocationRatsRats, Sprague-DawleyRisk FactorsZoledronic AcidBone Density Conservation AgentsDiphosphonatesImidazolesZoledronic AcidBisphosphonate-related osteonecrosis of the jawBisphosphonatesMicroarchitectureMicrocrackRat

Identifiers

PMID26795624
OpenAlexW2255461676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.