Observational studyJAMA ophthalmology2016
Automated Quantification of Capillary Nonperfusion Using Optical Coherence Tomography Angiography in Diabetic Retinopathy.
Observational study in JAMA ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 210 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Effect of Repeated Intravitreal Injections of Anti-VEGF on Macular Perfusion in Diabetic Patients Using Optical Coherence Tomography Angiography
Evaluation of Microvascular Changes in the Perifoveal Vascular Network Using Optical Coherence Tomography Angiography (OCT-A) in Type I Diabetes Mellitus
Who cites it
210 citing papers in PubMed, 4 syntheses or guidelines pooled it, 385 citations in OpenAlex.
- Comparing widefield and ultra-widefield optical coherence tomography angiography with fluorescein angiography in diabetic retinopathy: a review.International ophthalmology · 2026Pooled it
- Optical Coherence Tomography Angiography of Macular Perfusion Changes after Anti-VEGF Therapy for Diabetic Macular Edema: A Systematic Review.Journal of diabetes research · 2021Pooled it
- Review on Recent Trials Evaluating the Effect of Intravitreal Injections of Anti-VEGF Agents on the Macular Perfusion of Diabetic Patients with Diabetic Macular Edema.Reviews on recent clinical trials · 2020Pooled it
- The diagnostic value of optical coherence tomography angiography in diabetic retinopathy: a systematic review.International ophthalmology · 2019Pooled it
- A randomized controlled trial to test the efficacy of a diabetes behavioral intervention to prevent memory decline in older blacks/African Americans with diabetes and mild cognitive impairment.Contemporary clinical trials · 2022Trial
- Automated vessel density detection in fluorescein angiography images correlates with vision in proliferative diabetic retinopathy.PloS one · 2020Trial
- Evaluation of microvascular changes in the perifoveal vascular network using optical coherence tomography angiography (OCTA) in type I diabetes mellitus: a large scale prospective trial.BMC medical imaging · 2019Trial
- Retinal Capillary Loss Is More Severe in the Midperiphery Than in the Macula in Eyes With Diabetic Retinopathy Compared to Healthy Eyes.Translational vision science & technology · 2026Article
- Baseline Deep Capillary Plexus Ischemia Predicts Earlier Diabetic Retinopathy Complications Than Foveal Avascular Enlargement.American journal of ophthalmology · 2026Article
- Quantitative optical coherence tomography angiography analysis of retinal capillary plexuses in diabetic eyes: Impact of phakic and pseudophakic status.Indian journal of ophthalmology · 2026Observational
- Local Versus Global Binarization Techniques After Frangi Filtering for Optical Coherence Tomography Angiography Based Retinal Vessel Density Assessment in Diabetic Retinopathy.Diagnostics (Basel, Switzerland) · 2026Article
- Automated Nonperfusion Quantification in Diabetic Retinopathy on Ultra-Widefield Swept-Source OCT Angiography.Ophthalmology science · 2026Article
- Optical Coherence Tomography Angiography-Based Evaluation of Foveal Avascular Zone and Macular Vessel Density in Prediabetic Patients.The Eurasian journal of medicine · 2026Article
- OCT Angiography of Chorioretinal Microvasculature in Children with Type 1 and Type 2 Diabetes without Retinopathy.Ophthalmology science · 2026Article
- Relationship Between Foveal Avascular Zone Measured by Optical Coherence Tomography Angiography and Visual Acuity in Diabetic Retinopathy: A Systematic Review.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Ultra-widefield optical coherence tomography angiography in diabetic retinopathy: from retinal lesions to choroidal metrics.Frontiers in medicine · 2026Review
- Artificial intelligence in ophthalmic optical coherence tomography angiography: a bibliometric analysis.International journal of ophthalmology · 2026Article
- Analysis of correlations between biomarkers assessed with swept-source OCT and OCT angiography in naïve patients with diabetic macular edema treated with aflibercept: a prospective study.International journal of retina and vitreous · 2025Article
- Semantic segmentation of the avascular zone of the fovea in optical coherence tomography angiography: evaluation of techniques and applications in ocular diseases.International journal of retina and vitreous · 2025Article
- Quantifying Choriocapillaris Flow Deficits in Diabetic Retinopathy Using Projection-Resolved OCT Angiography.Investigative ophthalmology & visual science · 2025Article
150 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
importanceMacular ischemia is a key feature of diabetic retinopathy (DR). Quantification of macular ischemia has potential as a biomarker for DR.
objectiveTo assess the feasibility of automated quantification of capillary nonperfusion as a potential sign of macular ischemia using optical coherence tomography (OCT) angiography. DESIGN, SETTING, AND
participantsAn observational study conducted in a tertiary, subspecialty, academic practice evaluated macular nonperfusion with 6 × 6-mm OCT angiography obtained with commercially available 70-kHz OCT and fluorescein angiography (FA). The study was conducted from January 22 to September 18, 2014. Data analysis was performed from October 1, 2014, to April 7, 2015. Participants included 12 individuals with normal vision serving as controls and 12 patients with various levels of DR. MAIN OUTCOMES AND MEASURES: Preplanned primary measures were parafoveal and perifoveal vessel density, total avascular area, and foveal avascular zone as detected with 6 × 6-mm OCT angiography and analyzed using an automated algorithm. Secondary measures included the agreement of the avascular area between the OCT angiogram and FA.
resultsCompared with the 12 healthy controls (11 women; mean [SD] age, 54.2 [14.2] years), the 12 participants with DR (4 women; mean [SD] age, 55.1 [12.1] years) had reduced parafoveal and perifoveal vessel density by 12.6% (95% CI, 7.7%-17.5%; P < .001) and 10.4% (95% CI, 6.8%-14.1%; P < .001), respectively. Total avascular area and foveal avascular zone area were greater in eyes with DR by 0.82 mm2 (95% CI, 0.65-0.99 mm2; P = .02) and 0.16 mm2 (95% CI, 0.05-0.28 mm2; P < .001). The agreement between the vascular areas in the OCT angiogram and FA had a κ value of 0.45 (95% CI, 0.21-0.70; P < .001). Total avascular area in the central 5.5-mm-diameter area distinguished eyes with DR from control eyes with 100% sensitivity and specificity. CONCLUSIONS AND RELEVANCE: Avascular area analysis with an automated algorithm using OCT angiography, although not equivalent to FA, detected DR reliably in this small pilot study. Further study is necessary to determine the usefulness of the automated quantification in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.