ArticleNature communications2016
Complex disease and phenotype mapping in the domestic dog.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
166 citing papers in PubMed, 3 syntheses or guidelines pooled it, 276 citations in OpenAlex.
- Mass spectrometry-based proteomics profiling of dogs with and without oral diseases: a systematic review.BMC oral health · 2024Pooled it
- Genome-wide association studies for canine hip dysplasia in single and multiple populations - implications and potential novel risk loci.BMC genomics · 2021Pooled it
- Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals.Nature genetics · 2018Pooled it
- Genotypic and phenotypic consequences of domestication in dogs.G3 (Bethesda, Md.) · 2026Article
- Image feature embedding with a deep learning framework improves genome-wide association studies on dog endophenotypes.Science advances · 2026Article
- A Labrador PeptideAtlas and DIA spectral assay library - resources for proteomics research in dogs.Scientific data · 2026Article
- Phenome-wide study connects behavioral genetics of odor detection dogs with temperament traits.Scientific reports · 2026Article
- Behavioural susceptibility to environmental influences in obesity- evidence from a companion animal model.BMC veterinary research · 2026Article
- Transcriptomes of thirteen healthy feline tissue types.BMC genomics · 2025Article
- Fine-scale recombination rates inferred using the canFam4 assembly are strongly correlated with previous maps of dog recombination.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- A 120-y time series of genomes reveals the consequences of closed breeding in German Shepherd Dogs.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genetic testing predicts appearance but not behavior in dogs.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Imputation of ancient canid genomes reveals inbreeding history over the past 10,000 years.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Genomic Exploration of the Possible De-Extirpation of the Zanzibar Leopard.Molecular ecology · 2025Article
- Selective sweeps for mutations increasing height impede identification of causative mutations for fertility and other correlated traits in cattle.Genetics, selection, evolution : GSE · 2025Article
- Genotypic and phenotypic consequences of domestication in dogs.bioRxiv : the preprint server for biology · 2025Article
- Comment on Hladky-Krage, B.; Hoffman, C.L. Expectations versus Reality of Designer Dog Ownership in the United States.Animals : an open access journal from MDPI · 2025Article
- Genomic evidence for behavioral adaptation of herding dogs.Science advances · 2025Article
- Owner-Perceived Undesirable Behaviours in Young Dogs and Changes with Age.Animals : an open access journal from MDPI · 2025Article
- Cross-species analysis of genetic architecture and polygenic risk scores for non-contact ACL rupture in dogs and humans.Communications biology · 2025Article
106 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 3 institutions in 2 countries.
Funding
Abstract
The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and orthopaedic disease. Here we undertake the largest canine genome-wide association study to date, with a panel of over 4,200 dogs genotyped at 180,000 markers, to accelerate mapping efforts. For complex diseases, we identify loci significantly associated with hip dysplasia, elbow dysplasia, idiopathic epilepsy, lymphoma, mast cell tumour and granulomatous colitis; for morphological traits, we report three novel quantitative trait loci that influence body size and one that influences fur length and shedding. Using simulation studies, we show that modestly larger sample sizes and denser marker sets will be sufficient to identify most moderate- to large-effect complex disease loci. This proposed design will enable efficient mapping of canine complex diseases, most of which have human homologues, using far fewer samples than required in human studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.