ArticleImmunity2016
Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function.
Article in Immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 76 citations in OpenAlex.
- A guide to B cell metabolism.Nature reviews. Immunology · 2026Review
- Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer.Journal of translational medicine · 2025Article
- Defective mitochondria remodelling in B cells leads to an aged immune response.Nature communications · 2024Article
- Review
- Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders.Cell death & disease · 2022Article
- The Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocytes.International journal of molecular sciences · 2021Review
- Mechanistic connections between mitochondrial biology and regulated cell death.Developmental cell · 2021Review
- Mitochondrial Metabolism Regulation of T Cell-Mediated Immunity.Annual review of immunology · 2021Review
- Brd4 Regulates the Homeostasis of CD8Frontiers in immunology · 2021Article
- Mitochondrial-LinkedFrontiers in immunology · 2021Article
- The Importance of Metabolism for Immune Homeostasis in Allergic Diseases.Frontiers in immunology · 2021Review
- Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus.Molecular metabolism · 2020Article
- Chromon-3-aldehyde derivatives restore mitochondrial function in rat cerebral ischemia.Iranian journal of basic medical sciences · 2020Article
- Mild microwave ablation combined with HSP90 and TGF‑β1 inhibitors enhances the therapeutic effect on osteosarcoma.Molecular medicine reports · 2020Article
- YY1 control of mitochondrial-related genes does not account for regulation of immunoglobulin class switch recombination in mice.European journal of immunology · 2020Article
- Functionally significant metabolic differences between B and T lymphocyte lineages.Immunology · 2019Article
- Generation of T Cell Receptor Retrogenic Mice.Current protocols in immunology · 2019Article
- Regulation of metabolic supply and demand during B cell activation and subsequent differentiation.Current opinion in immunology · 2019Review
- Plasma cells: You are what you eat.Immunological reviews · 2019Review
- Sirtuins in B lymphocytes metabolism and function.World journal of experimental medicine · 2019Review
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
The role of apoptosis inducing factor (AIF) in promoting cell death versus survival remains controversial. We report that the loss of AIF in fibroblasts led to mitochondrial electron transport chain defects and loss of proliferation that could be restored by ectopic expression of the yeast NADH dehydrogenase Ndi1. Aif-deficiency in T cells led to decreased peripheral T cell numbers and defective homeostatic proliferation, but thymic T cell development was unaffected. In contrast, Aif-deficient B cells developed and functioned normally. The difference in the dependency of T cells versus B cells on AIF for function and survival correlated with their metabolic requirements. Ectopic Ndi1 expression rescued homeostatic proliferation of Aif-deficient T cells. Despite its reported roles in cell death, fibroblasts, thymocytes and B cells lacking AIF underwent normal death. These studies suggest that the primary role of AIF relates to complex I function, with differential effects on T and B cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.