ArticleNeuroradiology2016
Identifying the association between contrast enhancement pattern, surgical resection, and prognosis in anaplastic glioma patients.
Article in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Bi-exponential diffusion-weighted imaging for differentiating high-grade gliomas from solitary brain metastases: a VOI-based histogram analysis.Scientific reports · 2024Article
- Supramaximal Resection for Glioblastoma: Redefining the Extent of Resection Criteria and Its Impact on Survival.Brain tumor research and treatment · 2023Review
- Survival, Prognostic Factors, and Volumetric Analysis of Extent of Resection for Anaplastic Gliomas.Cancer research and treatment · 2020Article
- Machine learning and radiomic phenotyping of lower grade gliomas: improving survival prediction.European radiology · 2020Article
- Prognostic value of magnetic resonance imaging features in low-grade gliomas.Bioscience reports · 2019Article
- The added prognostic value of radiological phenotype combined with clinical features and molecular subtype in anaplastic gliomas.Journal of neuro-oncology · 2019Article
- Preoperative prediction of cavernous sinus invasion by pituitary adenomas using a radiomics method based on magnetic resonance images.European radiology · 2019Article
- The mediating role of extent of resection in the relationship between the tumor characteristics and survival outcome of glioma.Journal of Cancer · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionContrast enhancement observable on magnetic resonance (MR) images reflects the destructive features of malignant gliomas. This study aimed to investigate the relationship between radiologic patterns of tumor enhancement, extent of resection, and prognosis in patients with anaplastic gliomas (AGs).
methodsClinical data from 268 patients with histologically confirmed AGs were retrospectively analyzed. Contrast enhancement patterns were classified based on preoperative T1-contrast MR images. Univariate and multivariate analyses were performed to evaluate the prognostic value of MR enhancement patterns on progression-free survival (PFS) and overall survival (OS).
resultsThe pattern of tumor contrast enhancement was associated with the extent of surgical resection in AGs. A gross total resection was more likely to be achieved for AGs with focal enhancement than those with diffuse (p = 0.001) or ring-like (p = 0.024) enhancement. Additionally, patients with focal-enhanced AGs had a significantly longer PFS and OS than those with diffuse (log-rank, p = 0.025 and p = 0.031, respectively) or ring-like (log-rank, p = 0.008 and p = 0.011, respectively) enhanced AGs. Furthermore, multivariate analysis identified the pattern of tumor enhancement as a significant predictor of PFS (p = 0.016, hazard ratio [HR] = 1.485) and OS (p = 0.030, HR = 1.446).
conclusionOur results suggested that the contrast enhancement pattern on preoperative MR images was associated with the extent of resection and predictive of survival outcomes in AG patients.
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