Evidence map›Paper›PMID 26795083›Full record

ArticleClinical lymphoma, myeloma & leukemia2016

Doxorubicin-Based Chemotherapy and Radiation Therapy Produces Favorable Outcomes in Limited-Stage Plasmablastic Lymphoma: A Single-Institution Review.

Chelsea C Pinnix, Jatin J Shah, Hubert Chuang, Colleen M Costelloe, L Jeffrey Medeiros, Christine F Wogan, Valerie Reed, Grace L Smith, Sarah Milgrom, Krina Patel and 18 more

Open access · greenAbstract read
In one paragraph

Article in Clinical lymphoma, myeloma & leukemia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Sinonasal Plasmablastic Lymphoma: A Systematic Review.Journal of neurological surgery reports · 2024
    Article
  3. Plasmablastic Lymphoma. A State-of-the-Art Review: Part 2-Focus on Therapy.Mediterranean journal of hematology and infectious diseases · 2024
    Review
  4. Plasmablastic lymphoma: An update.International journal of laboratory hematology · 2022
    Review
  5. Article
  6. Article
  7. Plasmablastic lymphoma: current perspectives.Blood and lymphatic cancer : targets and therapy · 2018
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 1 institution in 1 country.

Chelsea C PinnixDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: ccpinnix@mdanderson.org.
Jatin J ShahDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Hubert ChuangDepartment of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Colleen M CostelloeDepartment of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX.
L Jeffrey MedeirosDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Christine F WoganDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Valerie ReedDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Grace L SmithDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Sarah MilgromDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Krina PatelDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Jinhai HuoDepartment of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, TX.
Francesco TurturroDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Jorge RomagueraDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Luis FayadDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Yasuhiro OkiDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Michelle A FanaleDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Jason WestinDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Loretta NastoupilDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Fredrick B HagemeisterDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Alma RodriguezDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Muzaffar QazilbashDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Nina ShahDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Qaiser BashirDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Sairah AhmedDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Yago NietoDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Chitra HosingDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Eric RohrenDepartment of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Bouthaina DabajaDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Economic Strain and Resilience in Cancer Patients: Assessing Patient-Reported Measures of the Burdens of TreatmentK07CA211804 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SMITH, GRACE · 2016 to 2020
$853k
NCI NIH HHS CA016672NCI NIH HHS K07 CA211804NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

backgroundPlasmablastic lymphoma (PBL) is an aggressive variant of diffuse large B-cell lymphoma. We sought to assess the treatment outcomes after combined-modality therapy for early-stage PBL. MATERIALS AND

methodsWe retrospectively reviewed the outcomes of 10 consecutive patients diagnosed with stage I-II PBL from February 2001 to December 2013 at a single institution. The baseline clinical characteristics, treatment modalities, overall outcomes, and treatment-related toxicity were assessed.

resultsThe median age at diagnosis was 50.5 years. All patients had extranodal disease; 2 were positive for human immunodeficiency virus. Seven patients received hyper-CVAD (cyclophosphamide, vincristine, doxorubicin, dexamethasone)-based chemotherapy, 2 received CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), and 1 received dose-adjusted EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin). Radiotherapy (RT) was administered after a complete response to chemotherapy in 7 patients and a partial response in 1 patient. At a median follow-up period of 42 months, the estimated 2-year progression-free and overall survival rates were 90% and 100%, respectively.

conclusionPBL can be successfully treated with aggressive chemotherapy followed by RT. The treatment was well tolerated and can result in long-term survival for patients with limited-stage disease.

Indexed as

RadiotherapyAdultAgedAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyDoxorubicinFemaleHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedNeoplasm StagingPlasmablastic LymphomaPositron-Emission TomographyRetrospective StudiesTomography, X-Ray ComputedDoxorubicinCombined modality therapyEarly stageNon-Hodgkin lymphomaRadiotherapySurvival

Identifiers

PMID26795083
PMCPMC9754636
OpenAlexW2216418481

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.