Trial reportParasite (Paris, France)2016
Assessment of the prophylactic speed of kill of Frontline Tri-Act(®) against ticks (Ixodes ricinus and Rhipicephalus sanguineus) on dogs.
Trial report in Parasite (Paris, France), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Six-month field efficacy and safety of the combined treatment of dogs with Frontline Tri-Act® and NexGard Spectra®.Parasites & vectors · 2018Trial
- Review
- Blocking transmission of vector-borne diseases.International journal for parasitology. Drugs and drug resistance · 2017Review
- Knock-down and speed of kill of a combination of fipronil and permethrin for the prevention of Ctenocephalides felis flea infestation in dogs.Parasites & vectors · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the study was to assess the speed of kill of a single topical treatment with a combination of fipronil and permethrin (Frontline Tri-Act(®)/Frontect(®)) against experimental infestations of Ixodes ricinus and Rhipicephalus sanguineus ticks on dogs. In this parallel group designed, randomised, single centre, controlled efficacy study, 16 healthy adult dogs were allocated to two groups: 8 dogs were treated with the topical combination on Day 0 and the other 8 dogs served as untreated controls. Each dog was exposed in a crate to 100 I. ricinus (50 females, 50 males) and 50 R. sanguineus (25 males, 25 females) on Days 2, 7, 14, 21 and 28. Ticks were counted in situ at 6 and 12 h after exposure and removed at 24 h after exposure. Frontline Tri-Act(®) was effective (≥90%) against both R. sanguineus and I. ricinus tick infestations at 6, 12 and 24 h after exposure, from 2 to 28 days after treatment. This is the first time that a topical ectoparasiticide has demonstrated a preventive killing effect against these two tick species in 6 h for a full month.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.