Evidence map›Paper›PMID 26794935›Full record

ArticleRadiology2016

MR Fingerprinting for Rapid Quantitative Abdominal Imaging.

Yong Chen, Yun Jiang, Shivani Pahwa, Dan Ma, Lan Lu, Michael D Twieg, Katherine L Wright, Nicole Seiberlich, Mark A Griswold, Vikas Gulani

Open access · greenAbstract read
In one paragraph

Article in Radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed
19.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 200 citations in OpenAlex.

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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yong ChenFrom the Departments of Radiology (Y.C., S.P., D.M., L.L., K.L.W., M.A.G., V.G.), Biomedical Engineering (Y.J., N.S., M.A.G.), and Electrical Engineering and Computer Science (M.D.T.), Case Western Reserve University/University Hospitals Case Medical Center, 11100 Euclid Ave, Bolwell Building, Room B120, Cleveland, OH 44106.
Yun JiangFrom the Departments of Radiology (Y.C., S.P., D.M., L.L., K.L.W., M.A.G., V.G.), Biomedical Engineering (Y.J., N.S., M.A.G.), and Electrical Engineering and Computer Science (M.D.T.), Case Western Reserve University/University Hospitals Case Medical Center, 11100 Euclid Ave, Bolwell Building, Room B120, Cleveland, OH 44106.
Shivani PahwaFrom the Departments of Radiology (Y.C., S.P., D.M., L.L., K.L.W., M.A.G., V.G.), Biomedical Engineering (Y.J., N.S., M.A.G.), and Electrical Engineering and Computer Science (M.D.T.), Case Western Reserve University/University Hospitals Case Medical Center, 11100 Euclid Ave, Bolwell Building, Room B120, Cleveland, OH 44106.
Dan MaFrom the Departments of Radiology (Y.C., S.P., D.M., L.L., K.L.W., M.A.G., V.G.), Biomedical Engineering (Y.J., N.S., M.A.G.), and Electrical Engineering and Computer Science (M.D.T.), Case Western Reserve University/University Hospitals Case Medical Center, 11100 Euclid Ave, Bolwell Building, Room B120, Cleveland, OH 44106.
Lan LuFrom the Departments of Radiology (Y.C., S.P., D.M., L.L., K.L.W., M.A.G., V.G.), Biomedical Engineering (Y.J., N.S., M.A.G.), and Electrical Engineering and Computer Science (M.D.T.), Case Western Reserve University/University Hospitals Case Medical Center, 11100 Euclid Ave, Bolwell Building, Room B120, Cleveland, OH 44106.
Michael D TwiegFrom the Departments of Radiology (Y.C., S.P., D.M., L.L., K.L.W., M.A.G., V.G.), Biomedical Engineering (Y.J., N.S., M.A.G.), and Electrical Engineering and Computer Science (M.D.T.), Case Western Reserve University/University Hospitals Case Medical Center, 11100 Euclid Ave, Bolwell Building, Room B120, Cleveland, OH 44106.
Katherine L WrightFrom the Departments of Radiology (Y.C., S.P., D.M., L.L., K.L.W., M.A.G., V.G.), Biomedical Engineering (Y.J., N.S., M.A.G.), and Electrical Engineering and Computer Science (M.D.T.), Case Western Reserve University/University Hospitals Case Medical Center, 11100 Euclid Ave, Bolwell Building, Room B120, Cleveland, OH 44106.
Nicole SeiberlichFrom the Departments of Radiology (Y.C., S.P., D.M., L.L., K.L.W., M.A.G., V.G.), Biomedical Engineering (Y.J., N.S., M.A.G.), and Electrical Engineering and Computer Science (M.D.T.), Case Western Reserve University/University Hospitals Case Medical Center, 11100 Euclid Ave, Bolwell Building, Room B120, Cleveland, OH 44106.
Mark A GriswoldFrom the Departments of Radiology (Y.C., S.P., D.M., L.L., K.L.W., M.A.G., V.G.), Biomedical Engineering (Y.J., N.S., M.A.G.), and Electrical Engineering and Computer Science (M.D.T.), Case Western Reserve University/University Hospitals Case Medical Center, 11100 Euclid Ave, Bolwell Building, Room B120, Cleveland, OH 44106.
Vikas GulaniFrom the Departments of Radiology (Y.C., S.P., D.M., L.L., K.L.W., M.A.G., V.G.), Biomedical Engineering (Y.J., N.S., M.A.G.), and Electrical Engineering and Computer Science (M.D.T.), Case Western Reserve University/University Hospitals Case Medical Center, 11100 Euclid Ave, Bolwell Building, Room B120, Cleveland, OH 44106.
University Hospitals of Cleveland · US

Funding

The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Florian Rieder · 2015 to 2026
$15.6M
Clinical and Translational Science Collaborative of ClevelandKL2TR000440 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$11.1M
Improved Cardiac and Vascular MRI Using Parallel Imaging and Compressed SensingR01HL094557 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GRISWOLD, MARK, SEIBERLICH, NICOLE · 2010 to 2018
$4.5M
Comprehensive quantitative ultrafast 3D liver MRIR01DK098503 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI GULANI, VIKAS, SEIBERLICH, NICOLE · 2013 to 2017
$2.6M
Magnetic Resonance Fingerprinting (MRF) for Improved High Field MRR01EB017219 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI GRISWOLD, MARK · 2013 to 2016
$2.5M
Optimization of MR Fingerprinting (MRF) for Quantitative MRIR01EB016728 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI GRISWOLD, MARK, GULANI, VIKAS · 2014 to 2017
$2.0M
Novel Fast Imaging and Reconstruction Strategies for Dynamic MRIR00EB011527 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI SEIBERLICH, NICOLE · 2012 to 2014
$719k
NCATS NIH HHS 2KL2TR000440NCATS NIH HHS KL2 TR000440NHLBI NIH HHS R01 HL094557NIBIB NIH HHS 1R01EB017219NIBIB NIH HHS 5R01EB016728NIBIB NIH HHS R00 EB011527NIBIB NIH HHS R00EB011527NIBIB NIH HHS R01 EB016728NIBIB NIH HHS R01 EB017219NIDDK NIH HHS 1R01DK098503NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK098503
6 · The paper itself

Abstract

purposeTo develop a magnetic resonance (MR) "fingerprinting" technique for quantitative abdominal imaging. MATERIALS AND

methodsThis HIPAA-compliant study had institutional review board approval, and informed consent was obtained from all subjects. To achieve accurate quantification in the presence of marked B0 and B1 field inhomogeneities, the MR fingerprinting framework was extended by using a two-dimensional fast imaging with steady-state free precession, or FISP, acquisition and a Bloch-Siegert B1 mapping method. The accuracy of the proposed technique was validated by using agarose phantoms. Quantitative measurements were performed in eight asymptomatic subjects and in six patients with 20 focal liver lesions. A two-tailed Student t test was used to compare the T1 and T2 results in metastatic adenocarcinoma with those in surrounding liver parenchyma and healthy subjects.

resultsPhantom experiments showed good agreement with standard methods in T1 and T2 after B1 correction. In vivo studies demonstrated that quantitative T1, T2, and B1 maps can be acquired within a breath hold of approximately 19 seconds. T1 and T2 measurements were compatible with those in the literature. Representative values included the following: liver, 745 msec ± 65 (standard deviation) and 31 msec ± 6; renal medulla, 1702 msec ± 205 and 60 msec ± 21; renal cortex, 1314 msec ± 77 and 47 msec ± 10; spleen, 1232 msec ± 92 and 60 msec ± 19; skeletal muscle, 1100 msec ± 59 and 44 msec ± 9; and fat, 253 msec ± 42 and 77 msec ± 16, respectively. T1 and T2 in metastatic adenocarcinoma were 1673 msec ± 331 and 43 msec ± 13, respectively, significantly different from surrounding liver parenchyma relaxation times of 840 msec ± 113 and 28 msec ± 3 (P < .0001 and P < .01) and those in hepatic parenchyma in healthy volunteers (745 msec ± 65 and 31 msec ± 6, P < .0001 and P = .021, respectively).

conclusionA rapid technique for quantitative abdominal imaging was developed that allows simultaneous quantification of multiple tissue properties within one 19-second breath hold, with measurements comparable to those in published literature.

Indexed as

AbdomenAdenocarcinomaAdultAgedAlgorithmsFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedPhantoms, Imaging

Identifiers

PMID26794935
PMCPMC4819902
OpenAlexW2263221359

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.