ArticleCell research2016
The kinase activity of PKR represses inflammasome activity.
Article in Cell research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.Journal of medicinal chemistry · 2026Article
- Lactic acid drives NLRP3 inflammasome activation and caspase-1-like cytokine cleavage via intracellular acidification.Cell death & disease · 2026Article
- Deciphering the multifaceted role of double-stranded RNA sensor protein kinase R: pathophysiological function beyond the antiviral response.RNA biology · 2025Review
- The Mechanism of Pyroptosis and Its Application Prospect in Diabetic Wound Healing.Journal of inflammation research · 2024Review
- HPV38 impairs UV-induced transcriptional activation of the IL-18 pro-inflammatory cytokine.mSphere · 2023Article
- Selective inhibition of PKR by C16 accelerates diabetic wound healing by inhibiting NALP3 expression in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- The protein kinase R modifies gut physiology to limit colitis.Frontiers in immunology · 2023Article
- Anti‑βInternational journal of molecular medicine · 2022Article
- DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.Science immunology · 2021Article
- Signaling pathways and intervention therapies in sepsis.Signal transduction and targeted therapy · 2021Review
- A tale of two proteins: PACT and PKR and their roles in inflammation.The FEBS journal · 2021Review
- Abortive HIV-1 RNA induces pro-IL-1β maturation via protein kinase PKR and inflammasome activation in humans.European journal of immunology · 2021Article
- Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders.International journal of environmental research and public health · 2021Review
- Protein Kinase R in Bacterial Infections: Friend or Foe?Frontiers in immunology · 2021Review
- Peroxynitrite/PKR Axis Modulates the NLRP3 Inflammasome of Cardiac Fibroblasts.Frontiers in immunology · 2020Article
- Article
- Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation.Frontiers in immunology · 2019Article
- A human cellular noncoding RNA activates the antiviral protein 2'-5'-oligoadenylate synthetase 1.The Journal of biological chemistry · 2018Article
- Novel aspects of the assembly and activation of inflammasomes with focus on the NLRC4 inflammasome.International immunology · 2018Review
- Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The protein kinase R (PKR) functions in the antiviral response by controlling protein translation and inflammatory cell signaling pathways. We generated a transgenic, knock-in mouse in which the endogenous PKR is expressed with a point mutation that ablates its kinase activity. This novel animal allows us to probe the kinase-dependent and -independent functions of PKR. We used this animal together with a previously generated transgenic mouse that is ablated for PKR expression to determine the role of PKR in regulating the activity of the cryopyrin inflammasome. Our data demonstrate that, in contradiction to earlier reports, PKR represses cryopyrin inflammasome activity. We demonstrate that this control is mediated through the established function of PKR to inhibit protein translation of constituents of the inflammasome to prevent initial priming during innate immune signaling. These findings identify an important role for PKR to dampen inflammation during the innate immune response and caution against the previously proposed therapeutic strategy to inhibit PKR to treat inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.