ArticleBioinformatics (Oxford, England)2016
Vasohibins: new transglutaminase-like cysteine proteases possessing a non-canonical Cys-His-Ser catalytic triad.
Article in Bioinformatics (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Condensation of MATCAP promotes CENP-E-dependent chromosome congression in mitosis.Nature communications · 2026Article
- Emerging enzymatic modifications and AI-driven strategies for smart tailoring of taste characteristics in food-derived peptides: A review.Food chemistry: X · 2026Review
- 3D-Mesenchymal stromal cells derived VASH2 alleviates oxidative stress-induced endothelial senescence by mediating α-tubulin detyrosination in systemic sclerosis.Journal of translational medicine · 2026Article
- Effects of microtubule (de)tyrosination on the morphology and motility of Trypanosoma brucei and cross-talk with polyglutamylation.Biology open · 2025Article
- Review
- Spatial arrangement, polarity, and posttranslational modifications of the microtubule system in the Drosophila eye.Cell and tissue research · 2024Article
- Identification of novel toxins associated with the extracellular contractile injection system using machine learning.Molecular systems biology · 2024Article
- Polyphasic Investigation of Aliiroseovarius salicola sp. nov., Isolated from Seawater.Current microbiology · 2024Article
- Identification and classification of papain-like cysteine proteinases.The Journal of biological chemistry · 2023Article
- Article
- VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules.The Journal of cell biology · 2023Article
- Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin.Current biology : CB · 2021Article
- Vasohibin 1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk.Development (Cambridge, England) · 2021Article
- The crystal structure of the tetrameric human vasohibin-1-SVBP complex reveals a variable arm region within the structural core.Acta crystallographica. Section D, Structural biology · 2020Article
- α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity.The Journal of cell biology · 2020Article
- Structural Analyses on the Deamidation of N-Terminal Asn in the Human N-Degron Pathway.Biomolecules · 2020Article
- Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer.Nature communications · 2019Article
- Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.Nature structural & molecular biology · 2019Article
- Structural basis of tubulin detyrosination by vasohibins.Nature structural & molecular biology · 2019Article
- Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis.Cell research · 2019Article
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2 authors.
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Abstract
unlabelledVasohibin-1 and Vasohibin-2 regulate angiogenesis, tumour growth and metastasis. Their molecular functions, however, were previously unknown, in large part owing to their perceived lack of homology to proteins of known structure and function. To identify their functional amino acids and domains, their molecular activity and their evolutionary history, we undertook an in-depth analysis of Vasohibin sequences. We find that Vasohibin proteins are previously undetected members of the transglutaminase-like cysteine protease superfamily, and all possess a non-canonical Cys-His-Ser catalytic triad. We further propose a calcium-dependent activation mechanism for Vasohibin proteins. These findings can now be used to design constructs for protein structure determination and to develop enzyme inhibitors as angiogenic regulators to treat metastasis and tumour growth. CONTACT: luis.sanchezpulido@dpag.ox.ac.uk SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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