Evidence map›Paper›PMID 26794279›Full record

ArticleBritish journal of cancer2016

Prognostic and diagnostic potential of miR-146a in oesophageal squamous cell carcinoma.

Cong Wang, Shanghui Guan, Fang Liu, Xuan Chen, Lihui Han, Ding Wang, Effat Un Nesa, Xintong Wang, Cihang Bao, Nana Wang and 1 more

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In one paragraph

Article in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  3. Prognostic Value of MicroRNAs in Esophageal Carcinoma: A Meta-Analysis.Clinical and translational gastroenterology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cong WangDepartment of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Shanghui GuanDepartment of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Fang LiuDepartment of Imaging, Shandong Medical College, Jinan, Shandong 250002, China.
Xuan ChenDepartment of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Lihui HanDepartment of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Ding WangDepartment of Laboratory Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Effat Un NesaDepartment of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Xintong WangDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, China.
Cihang BaoDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Nana WangDepartment of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Yufeng ChengDepartment of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccumulating evidence indicates that dysregulated microRNA-146a (miR-146a) is involved in tumour genesis and cancer progression. We aimed to evaluate its expression level and the potential for the diagnosis and prognosis in oesophageal squamous cell cancer (ESCC).

methodsWe examined miR-146a expression in 62 pairs of ESCC cancerous and matched paracancerous tissue, 115 formalin-fixed paraffin-embedded (FFPE) tissue samples and serum samples from 154 ESCC patients and 154 healthy volunteers using quantitative reverse transcription-PCR (qRT-PCR). Kaplan-Meier method, Cox regression and receiver-operating characteristic (ROC) curve analysis were applied to analyse its prognostic and diagnostic value.

resultsMicroRNA-146a expression level was significantly decreased in ESCC tissue compared with paracancerous tissue (P<0.001). Its regulation level was negatively associated with T factor and TNM stage. Kaplan-Meier curve revealed that its downregulation level predicted worse overall survival (OS) and progression-free survival (PFS). Both univariate and multivariate analyses identified miR-146a expression as independent prognostic factor for OS and PFS. Serum miR-146a was significantly reduced in ESCC patients than in healthy controls (P<0.001). Area under the curve ROC value, sensitivity and specificity for this marker were 0.863 ± 0.033, 85.7% and 68.6% in the Discovery Group, and 0.891 ± 0.027, 82.1% and 83.3% in the Validation Group.

conclusionsMicroRNA-146a is significantly reduced in cancerous tissue and serum samples of ESCC patients. It is an ideal biomarker for the prognosis and diagnosis of ESCC.

Indexed as

AgedBiomarkers, TumorCarcinoma, Squamous CellCase-Control StudiesDisease-Free SurvivalEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleGene Expression ProfilingHumansMaleMicroRNAsMiddle AgedMultivariate AnalysisNeoplasm GradingNeoplasm StagingBiomarkers, TumorMicroRNAsMIRN146 microRNA, human

Identifiers

PMID26794279
PMCPMC4742585

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.