ArticleBritish dental journal2016
Guidelines on prophylaxis to prevent infective endocarditis.
Article in British dental journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Infective endocarditis associated with left atrial appendage occlusion device: a contemporary systematic review.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Pooled it
- Oral health and orofacial pain in older people with dementia: a systematic review with focus on dental hard tissues.Clinical oral investigations · 2017Pooled it
- Trial
- Insights into amoxicillin pharmacokinetics using physiology-based pharmacokinetic modelling.Antimicrobial agents and chemotherapy · 2026Article
- Triple Valve Infective Endocarditis in an Immunocompetent Patient.JACC. Case reports · 2025Article
- Infective Endocarditis Among High-risk Individuals Before and After the Cessation of Antibiotic Prophylaxis in Dentistry: A National Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Impact of the COVID-19 Pandemic on Antibiotic Prescribing by Dentists in Galicia, Spain: A Quasi-Experimental Approach.Antibiotics (Basel, Switzerland) · 2022Article
- Infective endocarditis following invasive dental procedures: IDEA case-crossover study.Health technology assessment (Winchester, England) · 2022Observational
- Infective endocarditis and oral health-a Narrative Review.Cardiovascular diagnosis and therapy · 2021Review
- Temporal Trends of Infective Endocarditis in Olmsted County, Minnesota, Between 1970 and 2018: A Population-Based Analysis.Open forum infectious diseases · 2021Article
- Endocarditis prophylaxis in daily practice of pediatricians and dentists in Flanders.European journal of pediatrics · 2021Article
- Article
- Incidence of infective endocarditis caused by viridans group streptococci in Sweden - effect of cessation of antibiotic prophylaxis in dentistry for risk individuals.Journal of oral microbiology · 2020Article
- Atti Le giornate della ricerca scientificae delle esperienze professionali dei giovani: Società Italiana di Igiene, Medicina Preventiva e Sanità Pubblica (SItI) Roma 20-21 dicembre 2019.Journal of preventive medicine and hygiene · 2020Article
- Lingual Lymphangioma Ablation With High Power Diode Laser: A Case Report.Journal of lasers in medical sciences · 2020Article
- Designing a customized clinical practice guideline regarding antibiotic prophylaxis for Iranian general dentists.BMC oral health · 2019Article
- Infective endocarditis and the heavily restored dentition: are clinicians becoming more complacent regarding prevention?British dental journal · 2019Article
- Has common sense prevailed?British dental journal · 2018Article
- Antibiotic prophylaxis for dental procedures.Australian prescriber · 2017Review
- A change in the NICE guidelines on antibiotic prophylaxis: British Heart Valve Society update.BJGP open · 2017Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infective endocarditis is a devastating disease with high morbidity and mortality. The link to oral bacteria has been known for many decades and has caused ongoing concern for dentists, patients and cardiologists. Since 2008, the UK has been out of step with the rest of the world where antibiotic prophylaxis is recommended for high-risk patients undergoing invasive dental procedures. Recent evidence that identified an increase in endocarditis incidence prompted a guideline review by NICE and the European Society for Cardiology--which produces guidance for the whole of Europe. Despite reviewing the same evidence they reached completely opposing conclusions. The resulting conflict of opinions and guidance is confusing and poses difficulties for dentists, cardiologists and their patients. Recent changes in the law on consent, however, may provide a patient-centred and pragmatic solution to these problems. This Opinion piece examines the evidence and opposing guidance on antibiotic prophylaxis in the context of the recent changes in the law on consent and provides a framework for how patients at risk of endocarditis might be managed in practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.