ArticleEndoscopy international open2016
Solutions for submucosal injection in endoscopic resection: a systematic review and meta-analysis.
Article in Endoscopy international open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Sodium Alginate-Based Submucosal Lifting Hydrogel for Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection.Advanced healthcare materials · 2026Article
- Review
- Functional hydrogels as submucosal injectable materials in therapeutic endoscopy.Biomedical engineering letters · 2026Review
- Experimental model in porcines to evaluate solutions used in endoscopic resections.iGIE : innovation, investigation and insights · 2024Article
- Technical Advances in Endoscopic Resection Techniques for Lower GI Malignancies.Visceral medicine · 2024Review
- Endoscopic resection of large non-pedunculated colorectal polyps: current standards of treatment.eGastroenterology · 2024Review
- Injectable temperature-sensitive hydrogel facilitating endoscopic submucosal dissection.Frontiers in bioengineering and biotechnology · 2024Article
- Endoscopic mucosal resection: tips and tricks for gastrointestinal trainees.Translational gastroenterology and hepatology · 2023Review
- A review of hydrogels used in endoscopic submucosal dissection for intraoperative submucosal cushions and postoperative management.Regenerative biomaterials · 2023Review
- Easily-injectable shear-thinning hydrogel provides long-lasting submucosal barrier for gastrointestinal endoscopic surgery.Bioactive materials · 2022Article
- Endoscopic Mucosal Resection: Best Practices for Gastrointestinal Endoscopists.Gastroenterology & hepatology · 2022Article
- Endoscopic polypectomy devices.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2021Article
- Viscosity and degradation controlled injectable hydrogel for esophageal endoscopic submucosal dissection.Bioactive materials · 2021Article
- Off-label use of 0.4 % sodium hyaluronate teardrops: a safe and effective solution for submucosal injection in gastric endoscopic submucosal dissection.Endoscopy international open · 2020Article
- Computational Fluid Dynamics (CFD)-Based Optimization of Injection Process during Endoscopic Mucosal Therapy.Bioengineering (Basel, Switzerland) · 2020Article
- Features of endoscopic procedure site reaction associated with a recently approved submucosal lifting agent.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions.Journal of clinical medicine · 2020Article
- Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy.Pharmaceutics · 2020Article
- Endoscopically Injectable Shear-Thinning Hydrogels Facilitating Polyp Removal.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- A novel injectable thermo-sensitive binary hydrogels system for facilitating endoscopic submucosal dissection procedure.United European gastroenterology journal · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsSubmucosal injection is standard practice in endoscopic mucosal resection of gastrointestinal lesions. Several solutions are used. Our aim was to systematically review their efficacy and safety. PATIENTS AND
methodsWe performed a systematic review and meta-analysis using a random effects model of randomized controlled trials (RCTs) from MEDLINE. Studies in animal models were qualitatively assessed for efficacy and safety.
resultsIn total, 54 studies were qualitatively assessed. Eleven RCTs were analyzed, two of which were on endoscopic submucosal dissection (ESD). The quantitative synthesis included nine RCTs on endoscopic mucosal resection (EMR), comprising 792 subjects and 793 lesions. Mean lesion size was 20.9 mm (range 8.5 - 46 mm). A total of 209 lesions were randomized to sodium hyaluronate (SH) vs normal saline (NS), 72 to 50 % dextrose (D50) vs NS, 82 to D50 vs SH, 43 to succinylated gelatin, 25 to hydroxyethyl starch and 36 to fibrinogen. In total, 385 were randomized to NS as controls. NS and SH are the best studied solutions and seem to be equally effective in achieving complete resection (OR 1.09; 95 %CI 0.82, 1.45). No solution was proven to be superior in complete resection rate, post-polypectomy bleeding or coagulation syndrome/perforation incidence. Many solutions have been tested in animal studies and most seem more effective for mucosal elevation than NS.
conclusionsThere are several solutions in clinical use and many more under research, but most are poorly studied. SH seems to be clinically equivalent to NS. There are no significant differences in post-polypectomy complications. Larger RCTs are needed to determine any small differences that may exist between solutions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.