ArticleMedical journal of the Islamic Republic of Iran2015
Prevalence of osteoporosis and vitamin D receptor gene polymorphisms (FokI) in an Iranian general population based study (Kurdistan) (IMOS).
Article in Medical journal of the Islamic Republic of Iran, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2021Pooled it
- Association between vitamin D receptor BsmI, FokI, and Cdx2 polymorphisms and osteoporosis risk: an updated meta-analysis.Bioscience reports · 2020Pooled it
- Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A systematic review and Meta-Analysis.Scientific reports · 2018Pooled it
- Iranian Multicenter Osteoporosis Studies (IMOS) during last decade: rationale, main findings, lessons learned and the way forward.Journal of diabetes and metabolic disorders · 2024Review
- Association of rs4516035 Polymorphism with Osteoporosis in the Southeastern Iranian Population: A Case-Control Study.Journal of research in health sciences · 2024Article
- Vitamin D (Like Every Nutrient) is a Team Player.Integrative medicine (Encinitas, Calif.) · 2022Article
- VDR gene polymorphisms are associated with the increased susceptibility to COVID-19 among iranian population: A case-control study.International journal of immunogenetics · 2022Article
- Bone mass and microarchitecture in T2DM patients and corticosteroids therapy: the Bushehr Elderly Health program.Journal of diabetes and metabolic disorders · 2022Article
- Association of vitamin D receptor gene polymorphism with the occurrence of low bone density, osteopenia, and osteoporosis in patients with type 2 diabetes.Journal of diabetes and metabolic disorders · 2021Article
- Association of Vitamin D Concentrations with subjective health complaints in children and adolescents: the CASPIAN-V study.BMC public health · 2021Article
- Association of Vitamin D Receptor BsmI Gene Polymorphism with BMD Z-Score in Iranian Children and Adolescents (9 - 18 Years Old).International journal of endocrinology and metabolism · 2019Article
- Screening of differentially expressed genes in male idiopathic osteoporosis via RNA sequencing.Molecular medicine reports · 2018Article
- Economic inequalities amongst women with osteoporosis-related fractures: an application of concentration index decomposition.Health promotion perspectives · 2016Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporosis, or porous bone, is a disease characterized by low bone mass density (BMD) and structural deterioration of bone tissue, leading to bone fragility and increased risk of hip, spine, and wrist fractures. There are numerous risk factors for osteoporosis. While many of these factors are non-genetic in nature, there is a definite genetic component responsible for this condition. The main aim of this study was to evaluate the association between VDR (Vitamin D receptor gene) polymorphisms (Fok1) A>G (rs2228570) and bone mineral density in an Iranian defined population.
methodsThe study participants comprised of 1032 Iranians recruited from the city of Sanandaj during IMOS (Iranian Multi Center Osteoporosis Study). Bone mineral density measurement was performed in all the participants with and without osteoporosis. All samples were genotyped for VDR genes (Fok1) polymorphism with polymerase chain reaction, using a predesigned TaqMan allele discrimination assay.
resultsThere was a significant association between Fok1 polymorphism and osteoporosis in postmenopausal women, 0.138 (0.025-0.768).
conclusionIt seems that cohort studies, which are more powerful than case-control studies, can be useful in evaluating the roles of genetic variants as risk or protective factors for osteoporosis.
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Identifiers
26793629PMC4715426W2264273094What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.