Evidence map›Paper›PMID 26793416›Full record

ArticlePeerJ2016

Deciphering the microRNA transcriptome of skeletal muscle during porcine development.

Miaomiao Mai, Long Jin, Shilin Tian, Rui Liu, Wenyao Huang, Qianzi Tang, Jideng Ma, An'an Jiang, Xun Wang, Yaodong Hu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Miaomiao MaiCollege of Animal Science and Technology, Sichuan Agricultural University , Ya'an , People's Republic of China.
Long JinCollege of Animal Science and Technology, Sichuan Agricultural University , Ya'an , People's Republic of China.
Shilin TianNovogene Bioinformatics Institute , Beijing , People's Republic of China.
Rui LiuCollege of Animal Science and Technology, Sichuan Agricultural University , Ya'an , People's Republic of China.
Wenyao HuangCollege of Animal Science and Technology, Sichuan Agricultural University , Ya'an , People's Republic of China.
Qianzi TangCollege of Animal Science and Technology, Sichuan Agricultural University , Ya'an , People's Republic of China.
Jideng MaCollege of Animal Science and Technology, Sichuan Agricultural University , Ya'an , People's Republic of China.
An'an JiangCollege of Animal Science and Technology, Sichuan Agricultural University , Ya'an , People's Republic of China.
Xun WangCollege of Animal Science and Technology, Sichuan Agricultural University , Ya'an , People's Republic of China.
Yaodong HuCollege of Animal Science and Technology, Sichuan Agricultural University , Ya'an , People's Republic of China.
Dawei WangNovogene Bioinformatics Institute , Beijing , People's Republic of China.
Zhi JiangNovogene Bioinformatics Institute , Beijing , People's Republic of China.
Mingzhou LiCollege of Animal Science and Technology, Sichuan Agricultural University , Ya'an , People's Republic of China.
Chaowei ZhouDepartment of Aquaculture, Southwest University at Rongchang , Chongqing , People's Republic of China.
Xuewei LiCollege of Animal Science and Technology, Sichuan Agricultural University , Ya'an , People's Republic of China.
Sichuan Agricultural University · CNNovogene Bioinformatics Institute · CNSouthwest University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) play critical roles in many important biological processes, such as growth and development in mammals. Various studies of porcine muscle development have mainly focused on identifying miRNAs that are important for fetal and adult muscle development; however, little is known about the role of miRNAs in middle-aged muscle development. Here, we present a comprehensive investigation of miRNA transcriptomes across five porcine muscle development stages, including one prenatal and four postnatal stages. We identified 404 known porcine miRNAs, 118 novel miRNAs, and 101 miRNAs that are conserved in other mammals. A set of universally abundant miRNAs was found across the distinct muscle development stages. This set of miRNAs may play important housekeeping roles that are involved in myogenesis. A short time-series expression miner analysis indicated significant variations in miRNA expression across distinct muscle development stages. We also found enhanced differentiation- and morphogenesis-related miRNA levels in the embryonic stage; conversely, apoptosis-related miRNA levels increased relatively later in muscle development. These results provide integral insight into miRNA function throughout pig muscle development stages. Our findings will promote further development of the pig as a model organism for human age-related muscle disease research.

Indexed as

Middle-agedmiRNAMuscle developmentPorcinePostnatalPrenatal

Identifiers

PMID26793416
PMCPMC4715453
OpenAlexW2223313239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.