Evidence map›Paper›PMID 26793345›Full record

ArticleJournal of thoracic disease2015

A cross-sectional and follow-up study of leukopenia in tuberculosis patients: prevalence, risk factors and impact of anti-tuberculosis treatment.

Fei-Shen Lin, Mei-Ying Wu, Wen-Jun Tu, Hong-Qiu Pan, Jian Zheng, Jun-Wei Shi, Zhong-Ting Fei, Rui-Mei Zhang, Wei-Guo Yan, Ming-Qun Shang and 3 more

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Article in Journal of thoracic disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

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9citing papers in PubMed
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9 citing papers in PubMed.

  1. Article
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  4. [Probable neutropenia secondary to treatment with rifampicin].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025
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5 · Who and what money

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13 authors.

Fei-Shen Lin1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Mei-Ying Wu1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Wen-Jun Tu1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Hong-Qiu Pan1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Jian Zheng1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Jun-Wei Shi1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Zhong-Ting Fei1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Rui-Mei Zhang1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Wei-Guo Yan1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Ming-Qun Shang1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Qiang Zheng1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Meng-Jie Wang1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Xia Zhang1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the prevalence of and risk factors for leukopenia in tuberculosis patients and the impact of anti-tuberculosis regimens on the occurrence of leukopenia in newly treated tuberculosis patients.

methodsA total of 1,904 tuberculosis patients were included in the study. A cross-sectional survey of the prevalence of leukopenia was initially conducted, and then factors influencing leukopenia were identified using Logistic regression analysis. Non-treatment factors influencing peripheral blood leukocyte counts were analyzed using univariate COX proportional hazards models. Covariate analysis was used to assess the independent effect of different anti-tuberculosis regimens on peripheral blood leukocyte counts.

resultsBeing female, advanced age and longer duration of previous anti-tuberculosis treatment (>6 month) were risk factors for leukopenia in tuberculosis patients, while secondary pulmonary tuberculosis, higher body mass index (BMI: 24-27.9 kg/m(2)), and higher degree of education (senior high school or above) were protective factors. Gender, vegetable consumption, drinking, pulmonary infection, other chronic diseases, and use of antibiotics were significantly associated with the development of leukopenia in patients on anti-tuberculosis treatment. In tuberculosis patients treated with anti-tuberculosis regimens not containing antibiotics, peripheral blood leukocyte levels gradually declined with the prolongation of treatment duration. In tuberculosis patients treated with anti-tuberculosis regimens containing antibiotics, peripheral blood leukocyte levels showed a declining trend.

conclusionsFemale patients, patients at advanced age and recurrent tuberculosis patients having longer previous anti-tuberculosis treatment are high-risk populations for leukopenia. Attention should be paid to the influence of vegetable consumption and drinking, co-morbidities and use of antibiotics during anti-tuberculosis treatment.

Indexed as

anti-tuberculosis treatmentleukopeniarisk factorsTuberculosis

Identifiers

PMID26793345
PMCPMC4703664

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